The relationship between the activity and the chemical structure of cadeguomycin (CDM, 7-carboxy-7-deazaguanosine) was studied with six analogs of CDM. Both activities of CDM, enhancing the incorporation of [3H]thymidine in K562 cells and potentiating the cytotoxicity of cytosine arabinoside for K562 cells, were significantly augmented by the replacement of the 7-carboxyl group with cyano (CDM-...

Prostate cancer, acne, seborrhea, hirsutism, and androgenic alopecia are well recognized to depend upon an excess or increased sensitivity to androgens or to be at least sensitive to androgens. It thus seems logical to use antiandrogens as therapeutic agents to prevent androgens from binding to the androgen receptor. The two predominant naturally occurring androgens are testosterone (T) and dih...

The second-order rate constants for the microbial transformation of a series of phenols were correlated with the physicochemical properties of the phenols. The compounds studied were phenol, p-methylphenol, p-chlorophenol, p-bromophenol, p-cyanophenol, p-nitrophenol, p-acetylphenol, and p-methoxyphenol. Phenol-grown cells of Pseudomonas putida U transformed these compounds. Microbial transforma...

The activities of eight cytokinins in promoting callus growth were tested In two Phaseolus genotypes, P. vulgaris L. var. Great Northern, and P. lunatus L. var. Kingston. The structural feature which contributes to the major genotypic difference in cytokinin structure-activity relationships is the presence or absence of a double bond at the 2,3position of the isoprenoid Nf side chain. In Kingst...

activity and a wide spectrum against both Gram-positive and Gram-negative bacteria1~4). This high activity is due to good diffusion through the outer membranein Gram-negative organisms5), high affinities for penicillinbinding proteins (PBPs)6'7) and high stability and inhibitory activity against /Mactamases8). However, carbapenems were hydrolyzed by dehydropeptidase-I (DHP-I) from several anima...

Au-based catalysts have great potential because of their unique activity and selectivity for a variety of important reactions. The special catalytic properties of supported Au nano-particles depend critically upon the particle morphology, i.e. size, shape and thickness, as well as support effects. This paper reviews the current understanding of CO oxidation on supported Au catalysts. The electr...

In continuing with the research program initiated by Llored and Harré of exploring the part/whole (mereological) discourses of chemistry, we analyse Quantitative Structure-Activity Relationships (QSAR) studies, which are widespread approaches for modeling substances’ properties. The study is carried out by analyzing a particular QSAR model, and it is found that different mereologies are needed:...

We have implemented a general-purpose algorithm for planning appropriate joint activities in the context of an interactive system that has a long-term relationship with its user. The algorithm is data-directed and explicitly models the difference between relationship stages, such as stranger, acquaintance and companion. We have conducted a short laboratory evaluation of the algorithm that demon...

ABSTRACT Coumermycin A1 was early recognized as a potentially useful antibiotic because of its very good spectrum of activity against gram-positive organisms (particularly against staphylococci), in addition to appreciable activity against a variety of gram-negative bacteria. However, in spite of its excellent in vitro activity, the insoluble character of coumermycin A1 made parenteral administ...

Insects make up the largest and most diverse group of organisms on earth with several million species to exist in total. Considering the sheer number of insect species and the vast variety of ways they interact with their environment through chemistry, it is clear that they have significant potential as a source of new lead molecules. They have adapted to a range of ecological habitats and exhi...