Recently, a rising interest is given to neuroimmune communication in physiological and neuropathological conditions. Meningeal immunity complex immune environment housing different types of cells. Here, we focus on meningeal T cells, possibly the most explored aspect neuro-immune cell interactions. Emerging data have shown that cells play crucial role pathogenesis several neurodegenerative diso...

The present report discusses the immune and clearance system of central nervous (CNS) in terms its anatomical, physiological, biochemical properties. There is now a growing body evidence that progressive dysfunction meningeal lymphatic should be considered as risk factor for aging-related brain disorders. In addition, activity lymphatics may alter access CSF-carried neuromodulators to parenchym...

AIM To assess anti-neuronal antibodies (NA) prevalence and their correlation with neurological disorders and bowel habits in celiac disease (CD) patients. BACKGROUND Neurological manifestations are estimated to occur in about 10% of celiac disease patients and NA to central nervous system (CNS) and enteric nervous system (ENS) are found in a significant proportion of them. Little is known abo...

increasing incidence of central nervous system (cns) disorders has become a major challenge for both basic and clinical scientific society to develop novel therapeutic models for treatment. the knowledge of stem cells has added a new dimension in the research towards finding more appropriate targets responsible for the disease fate determination. as stem cell research is progressing day by day ...

Abstract Purpose of Review We describe the evolution and limitations current diagnostic criteria classification systems CNS hypersomnolence disorders propose some changes. Recent Findings An unsupervised cluster analysis 1100 Europeans with identified narcolepsy type 1 phenotype but not other categories listed in ICSD-3. Summary There are long-standing unsolved issues regarding diagnosis centra...