BACKGROUND AND PURPOSE We determined the effect of chronic hyperglycemia associated with diabetes on recovery of cerebral pH after global incomplete cerebral ischemia. METHODS 31P magnetic resonance spectra and cerebral blood flow (radiolabeled microspheres) were measured in three groups of dogs: (1) chronic hyperglycemic diabetes (pancreatectomy followed by blood glucose > 10 mmol/L for 3 mo...

Acute ischemic insults to the kidney are recognized complications of human sickle cell disease (SCD). The present study analyzed in a transgenic SCD murine model the early renal response to acute ischemia. Renal hemodynamics were profoundly impaired following ischemia in sickle mice compared with wild-type mice: glomerular filtration rate, along with renal plasma flow and blood flow rates, were...

Ischemia reperfusion injury occurs in the kidney when blood supply is interrupted in clinical settings such as kidney transplantation or nephron sparing surgery for renal tumors. These lesions lead to acute kidney injury (AKI) a detrimental situation associated with impaired short-term allograft function (delayed graft function or primary non function) but also long-term transplant survival thr...

Acute limb ischemia is rare in patients with venous thromboembolism who already receive anticoagulation treatment. Inflammation a risk factor for thrombus formation. Patients active ulcerative colitis, especially at the time of exacerbation, are more prone to thromboembolism, both and arterial. The thrombosis 18% higher, higher bleeding. To date, there no contraindication any anticoagulant drug...

TGF-β1 contributes to chronic kidney disease, at least in part, via Smad3. TGF-β1 is induced in the kidney following acute ischemia, and there is increasing evidence that TGF-β1 may protect against acute kidney injury. As there is a paucity of information regarding the functional significance of Smad3 in acute kidney injury, the present study explored this issue in a murine model of ischemic ac...

INTRODUCTION Patients with acute chest pain remain a great diagnostic challenge to emergency physicians. It is estimated that 30% of patients presenting with chest pain will be diagnosed with an acute coronary syndrome. [1] However, none of the traditional clinical data, 12-lead ECG, biochemical markers of necrosis, or imaging techniques can be considered a true gold standard for the diagnosis ...