Fuzzy expert systems are one of the most practical intelligent models with the high potential for managing uncertainty associated to the medical diagnosis. In this paper, a fuzzy inference system (FIS) for diagnosing of acute lymphocytic leukemia in children has been introduced. The fuzzy expert system applies Mamdani reasoning model that has high interpretability to explain system results to e...

The colony-forming potential of peripheral blood cells from ten patients with acute lymphocytic leukemia, as well as their urinary colony-stimulating activity levels, has been studied. Peripheral white blood cells from 4 of 10 patients with acute lymphocytic leukemia formed significant numbers of colonies when grown on feeder layers of normal human white blood cells. The colonies were composed ...

Leukocytes express a major sialoglycoprotein, leukosialin, of which the apparent molecular weight (mol wt) can be variable according to the differences in O-glycans attached to this molecule. In the present study, we analyzed the structures of O-glycans attached to leukosialin present in various T-lymphocytic leukemia cells. T-lymphoid cells from patients with acute T-lymphocytic leukemia expre...

The chromosomal translocation t(14;18)(q32;q21) is commonly associated with neoplasms of follicular center cell origin and has also been reported in cases of chronic lymphocytic leukemia. However, T cell acute lymphoblastic (or lymphocytic) leukemia (T-ALL) with t(14;18)(q32;q21) has been rarely reported. Here, we report a case of myeloid antigen-positive T-ALL (My+T-ALL) with t(14;18)(q32;q21)...

BACKGROUND Clinical management of chronic lymphocytic leukemia patients has changed considerably over the last years, reflected in an increased use of prognostic markers, new therapeutic agents and procedures, and supportive care measures. However, to date, clinical trials have not shown a survival benefit. DESIGN AND METHODS Using population-based data from Sweden, we assessed variations in ...

A case is described of acute leukemia whose neoplastic cells possessed myeloid and lymphoid characteristics. Neoplastic cells possessed cytoplasmic granules containing Sudan black B material and diaminobenzidine myeloperoxidase. In addition, these luekemic cells were positive for terminal deoxynucleotidyl transferase. Ia antigen, and the common acute lymphocytic leukemia antigen. These findings...