Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinosi...

The incidence of acute biphenotypic leukaemia has ranged from less than 1% to almost 50% in various reports in the literature. This wide variability may be attributed to a number of reasons including lack of consistent diagnostic criteria, use of various panels of antibodies, and the failure to recognize the lack of lineage specificity of some of the antibodies used. The morphology, cytochemist...

Tyrosol is a phenolic found in extra virgin olive oil (EVOO). In Maltese monocultivar EVOO, it was present at concentration of 9.23 ppm. The HL-60 acute myeloid leukaemia cell line, which can be differentiated to both monocytes and neutrophils, exposed tyrosol this analysed for evidence differentiation effects cytotoxicity. polyphenol induced 1.93-fold increase cellular oxidative activity (p-va...

Clinics and pathology Disease Myeloid malignancies: myelodysplastic syndrome (MDS) in 1/4 of cases, with various FAB diagnoses (refractory anaemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML)), acute non lymphocytic leukaemia (ANLL) in 60% of cases (M2-ANLL in 1/4 of all cases), blast crisi...

Granulocytic sarcomas of the small bowel are rare. They are discrete tumours of leukaemic myeloblasts and partially matured granulocytes that form in any part of the body. This disease is infrequently seen in patients with acute myeloid leukaemia, and rarely seen in patients without leukaemia. Here we report a case of small bowel obstruction due to granulocytic sarcoma of mid-ileum in a non-leu...

A balanced translocation t(8;9) (p11;q34) was present in the peripheral blood, bone marrow, and spleen cells of a patient with Ph negative chronic myeloid leukaemia. Subsequent transformation into acute leukaemia was associated with the emergence of trisomy 8 and der(8)(8qter----cen----8p11::9q34----9qter). This is the third reported case of t(8;9) (p11;q34) and raises the question of the role ...

Myeloid sarcoma is rare and nasal chloroma an uncommon initial manifestation of acute myeloid leukaemia. The correct diagnosis a big challenge. In this report, we present case the cavity with extension to soft tissues face. A 53-year-old woman past medical history thalassemia, not followed up, presented progressive greyish swelling in her right cheek associated obstruction more marked on side u...

There are many genes involved in vitamin D dependent differentiation of acute myeloid leukaemia cell line HL-60 cells. Involvement of HOX genes in leukaemia and differentiation is just beginning to be appreciated. In order to understand the relationship with 1,25(OH)2D3 dependent differentiation of myeloid leukaemia, we studied the expression of HOX A9 gene. HL-60 cells were exposed to 1,25(OH)...

The K562 Chronic Myeloid Leukaemia Cell Line undergoes Apoptosis in Response to 4-chloro-5-iodo-7H-pyrrolo[2.3-d]pyrimidine