نتایج جستجو برای: acute myeloid leukemia

تعداد نتایج: 704270  

2013
Charles E. Egwuagu Robert G. Hawley Qingdi Quentin Li Harold K Elias Arun S Shet

Thrombotic complications are known as accepted feature of acute myeloid leukemia and tend to occur in patients with hyperleucocytosis. Acute myocardial infarction, though reported is a rare clinical presentation in patients with this subtype of leukemia. We describe an unusual case of acute myeloid leukemia in a patient with leucopenia presenting with an acute myocardial infarction. The possibl...

Fatemeh Rajabipour, Negar Sajjadian,

Background: Acute leukemia is one of the most common types of childhood malignancies and one fourth of malignancies in this age group is acute leukemia. Acute leukemia may be myeloid or lymphoid. Acute lymphoblastic leukemia is characterized with abnormal proliferation of lymphoid cells and symptoms related to this are acute and if disease is not treated appropriately, it progresses rapidly and...

Journal: :International journal of clinical and experimental pathology 2015
Biao Zhu Jianbo Zhang Xiaodong Wang Jiao Chen Chenglong Li

Recent studies have shown that Th17 cells may be involved in the pathological process of acute myeloid leukemia. This CD4+ cell subgroup secretes highly homologous interleukin (IL)-17A and IL-17F, and also expresses IL-23 receptor (IL-23R) on the cell surface. Our study aims to investigate the relationship of IL-17A, IL-17F, and IL23R with disease susceptibility, and clarify the relationship be...

2013
Laura Quotti Tubi Carmela Gurrieri Alessandra Brancalion Laura Bonaldi Roberta Bertorelle Sabrina Manni Laura Pavan Federica Lessi Renato Zambello Livio Trentin Fausto Adami Maria Ruzzene Lorenzo A Pinna Gianpietro Semenzato Francesco Piazza

BACKGROUND The involvement of protein kinase CK2 in sustaining cancer cell survival could have implications also in the resistance to conventional and unconventional therapies. Moreover, CK2 role in blood tumors is rapidly emerging and this kinase has been recognized as a potential therapeutic target. Phase I clinical trials with the oral small ATP-competitive CK2 inhibitor CX-4945 are currentl...

Journal: :international journal of hematology-oncology and stem cell research 0
priya subashchandrabose assistant professor, department of pathology, saveetha medical college, chennai, india lakshmikanth ramiah madanagopaal chief of lab and consultant pathologist, department of pathology, dr lal path labs, chennai, india tadury madhukar subba rao professor, department of pathology, psg institute of medical sciences and research, coimbatore, india

background: acute leukemias are characterized by neoplastic proliferation of hematopoietic stem cells and accumulation of blasts and immature cells in the bone marrow. we applied a selective panel of immunohistochemical markers on bone marrow trephine tissue sections and observed their utility in diagnosis and typing of acute leukemia. materials and methods: the study was done at psg institute ...

Journal: :Haematologica 2009
Fernando P G Silva Inês Almeida Bruno Morolli Geeske Brouwer-Mandema Hans Wessels Rolf Vossen Harry Vrieling Erik W A Marijt Peter J M Valk Hanneke C Kluin-Nelemans Wolfgang R Sperr Wolf-Dieter Ludwig Micheline Giphart-Gassler

BACKGROUND Minimally differentiated acute myeloid leukemia is heterogeneous in karyotype and is defined by immature morphological and molecular characteristics. This originally French-American-British classification is still used in the new World Health Organization classification when other criteria are not met. Apart from RUNX1 mutation, no characteristic molecular aberrations are recognized....

2017
Zhihong Zeng Wenbin Liu Twee Tsao YiHua Qiu Yang Zhao Ismael Samudio Dos D. Sarbassov Steven M. Kornblau Keith A. Baggerly Hagop M. Kantarjian Marina Konopleva Michael Andreeff

The bone marrow microenvironment is known to provide a survival advantage to residual acute myeloid leukemia cells, possibly contributing to disease recurrence. The mechanisms by which stroma in the microenvironment regulates leukemia survival remain largely unknown. Using reverse-phase protein array technology, we profiled 53 key protein molecules in 11 signaling pathways in 20 primary acute m...

2017
Ruiqi Zhu Weiwei Zhao Fengjuan Fan Liang Tang Jingdi Liu Ting Luo Jun Deng Yu Hu

Acute myeloid leukemia is a hematologic malignancy with significant molecular heterogeneity. MicroRNAs have important biological functions and play critical roles in pathogenesis and prognosis in a variety of cancers including acute myeloid leukemia. Some reports have constructed risk stratification systems for adult acute myeloid leukemia patients using microRNAs to predict an optimal outcome ...

2003
Hartmut Dohner Diane C. Arthur Edward D. Ball Charles A. Schiffer

A new recurring chromosome abnormality was identified in 8 of 621 consecutive successfully karyotyped adults with de novo acute leukemia. These eight patients had trisomy 13 as the sole cytogenetic abnormality. On central morphologic review, five cases were classified as subtypes of acute myeloid leukemia, one as acute mixed lymphoid and myeloid leukemia, one as acute lymphoid leukemia, and one...

Journal: :Haematologica 2011
Maria Stefania De Propris Sara Raponi Daniela Diverio Maria Laura Milani Giovanna Meloni Brunangelo Falini Robin Foà Anna Guarini

The CD33 antigen is expressed on the blast cells of most cases of acute myeloid leukemia and represents a suitable tumor-associated target antigen for antibody-based therapies. The aim of this study was to investigate the relationship between the CD33 levels quantified by mean fluorescence intensity and antibody binding capacity, and the presence/absence of NPM1 and FLT3 gene mutations in 99 ne...

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