chemotherapeutic agents used in patients with cancer cause to generate the enormous amounts of free radicals associated with cell injury. in this study we assess the effects of chemotherapy regimen on oxidant/antioxidant status in patients with acute myeloid leukemia (aml). 38 newly diagnosed patients with acute myeloid leukemia were recruited in this study. all patients received cytarabine and...

Acute myeloid leukemia (AML) is the most common form of acute leukemia. Contemporary chemotherapy regimens fail to cure most patients with AML. We have genetically engineered a recombinant diphtheria toxin human granulocyte macrophage colony-stimulating factor (GMCSF) chimeric fusion protein (DTctGMCSF) that specifically targets the GMCSF receptor on fresh human AML cells and myeloid leukemia c...

Acute myeloid leukemia (AML) is a myeloid disorder with several established treatment regimens depending on patient and leukemic factors. Cisplatin is known to have strong leukemogenic potential and is rarely used even as salvage therapy in relapsed or refractory AML. We present a patient simultaneously diagnosed with AML and squamous cell carcinoma of the larynx, who was found to be in complet...

Biologically, Acute myeloid leukemia (AML) is highly heterogenous. AML with cup-like blast morphology variant has been reported to have important role in risk group stratification and treatment implications. In pediatric age group, this morphology and its clinical implication is rarely discussed. Although this morphology variant is not stated in World Health Organization (WHO) classification of...

Myelodysplastic syndrome (MDS) is characterized by clonal hematopoiesis and impaired differentiation, may develop to acute myeloid leukemia (AML). We explored the mechanism of histone methyltransferase EZH2/EHMT2 during transformation MDS into AML. Expression in patients NHD13 mice was detected. EZH2 EHMT2 were silenced or overexpressed SKM-1 cells. The cell proliferation cycle evaluated. Level...

Ratios of immunoproteasome over constitutive proteasome expression are an indicator for sensitivity to bortezomib-containing reinduction chemotherapy in pediatric relapsed acute lymphocytic leukemia and acute myeloid leukemia Manuscript in preparation 8 152 ABSTRACT Bortezomib, a proteasome inhibitor, is in Phase 3 clinical trials for the treatment of pediatric acute myeloid leukemia (AML) and ...

Background. The World Health Organization separates acute erythroid leukemia (erythropoiesis in ≥50% of nucleated bone marrow cells; ≥20% myeloblasts of non-erythroid cells) from other entities with increased erythropoiesis–acute myeloid leukemia with myelodysplasia-related changes (≥20% myeloblasts of all nucleated cells) or myelodysplastic syndromes, and subdivides acute erythroid leukemia in...

A 50-year-old woman was diagnosed with acute myeloid leukemia (AML). She has history of thrombocytopenia for 25 years and a significant family history of thrombocytopenia, affecting her mother, siblings and their children, as well as her own children. Both her mother and maternal aunt died from myelodysplastic syndrome (MDS). Additional genetic analysis was performed and identified two heterozy...

The production of blood cells is affected by leukemia, a type bone marrow cancer or cancer. Deoxyribonucleic acid (DNA) related to immature cells, particularly white and damaged in various ways this disease. When radiologist involved diagnosing acute leukemia the diagnosis time consuming needs provide better accuracy. For purpose, many types research have been conducted for automatic leukemia. ...