OBJECTIVES To determine the prevalence and determinants of acute pancreatitis in patients with acute brucellosis. METHODS Adult patients with brucellosis were retrospectively recruited. Brucellosis and acute pancreatitis were diagnosed according to standard criteria. Laboratory analyses included Wright agglutination titre, serum biochemical parameters and blood count. RESULTS Patients with ...

OBJECTIVES To assess the role of serum amylase and lipase in the diagnosis of acute pancreatitis. Secondary aims were to perform a cost analysis of these enzyme assays in patients admitted to the surgical admissions unit. DESIGN Cohort study. SETTING Secondary care. PARTICIPANTS Patients admitted with pancreatitis to the acute surgical admissions unit from January to December 2010 were in...

BACKGROUND The incidence of acute pancreatitis shows regional variations in the UK. AIMS To document the incidence and presentation of acute pancreatitis in hospitals in Wessex, and to audit the process and outcome of management of patients against the UK guidelines. METHODS A prospective survey was carried out of all patients with acute pancreatitis in a one year period, in eight geographi...

CONTEXT Acute pancreatitis is usually due to well-known causes, such as biliary lithiasis and alcohol consumption. Anatomic abnormalities may represent a less frequent but important etiological factor. CASE REPORT The case of a 27 year old women complaining of acute pancreatitis associated with a large duodenal juxta-papillary diverticulum is presented. CONCLUSIONS Anatomic causes of pancre...

CONTEXT Release of genomic DNA into plasma as a result of necrotic and apoptotic pathways is a feature of a range of human tumours. Severe acute pancreatitis is characterized by inflammation but may also be associated with accelerated apoptotic and necrotic pathways. OBJECTIVES This study uses quantitative real-time PCR to measure free circulating DNA in patients with severe acute pancreatiti...

Fifty one patients (median age 78, range 54-92) who had endoscopic sphincterotomy for gall stone pancreatitis without planned cholecystectomy were followed up to assess the effectiveness of this treatment in preventing further acute pancreatitis. In 48 patients sphincterotomy was technically successful and none had further acute pancreatitis after a mean follow up of 26.9 months. In three patie...

Pancreatitis is a disease which is caused by inflammation of the pancreas. Pancreas is a large gland that is damaged when digestive enzymes are become activated before releasing into small intestine and these digestive enzymes attack the pancreas. There are two main types of pancreatitis, one is acute pancreatitis and the other is chronic pancreatitis. The pain sometimes goes into the back. Fev...

BACKGROUND The early prediction of the severity of acute pancreatitis still represents a challenge for clinicians. Experimental studies have revealed the generation of specific halogenated lipids, in particular oleic acid chlorohydrin, in the early stages of acute pancreatitis. We hypothesized that the levels of circulating oleic acid chlorohydrin might be a useful early prognostic biomarker in...

In acute pancreatitis, reductions in blood flow and alterations of microvascular integrity resulting in impaired tissue oxygenation play an important part in the progression and possibly the initiation of the disease. Independently of the initial noxa, the intra-pancreatic activation of trypsinogen to trypsin is the crucial trigger of acute pancreatitis. The central events for the further cours...

IMPORTANCE Oral glucocorticoid use has been suggested to cause acute pancreatitis in several case reports. However, no epidemiological study has investigated this association. OBJECTIVE To conduct a nationwide population-based case-control study to investigate the potential association between oral glucocorticoid use and acute pancreatitis. DESIGN In this population-based case-control study...