نتایج جستجو برای: acute promyelocytic leukemia
تعداد نتایج: 688410 فیلتر نتایج به سال:
1. Zelent A, Guidez F, Melnick A, Waxman S, Licht JD. Translocations of the RARα gene in acute promyelocytic leukemia. Oncogene 2001;20:7186-203. 2. Catalano A, Dawson MA, Somana K, Opat S, Schwarer A, Campbell LJ, et al. The PRKAR1A gene is fused to RARA in a new variant acute promyelocytic leukemia. Blood 2007;110:4073-6. 3. Kwok C, Zeisig BB, Dong S, So CW. Forced homooligomerization of RARα...
RATIONALE Acute promyelocytic leukemia (APL) is a curable subtype of acute myeloid leukemia. APL is currently treated with combination of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) resulting in the induction of apoptosis and differentiation of the leukemic cells. Differentiation syndrome (so-called ATRA syndrome) is the main life-threatening complication of induction therapy with...
The translocation between chromosomes 15 and 17 t(15;17) at the promyelocytic leukemia (PML) retinoic acid receptor alpha (RARA) is thought to be specific for acute (APL). We present a case of with evidence by banding karyotype, FISH, PCR, rare microgranular promyelocytes significant basophilia detected on marrow aspirate, an ETV6 missense mutation molecular diagnostic testing. patient underwen...
Previous investigations of cancer survivors report that the cumulative incidence of subsequent leukemia plateaus between 10 and 15 years after primary therapy. Risk beyond 15 years has not been comprehensively assessed, primarily because of lack of long-term follow-up. Among 5-year survivors from the Childhood Cancer Survivor Study cohort, 13 pathologically confirmed cases of subsequent leukemi...
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