Polyethylene glycol is a synthetic, biodegradable, and water-soluble polyether. Owing to its good biological and material properties, polyethylene glycol shows promise in spinal cord tissue engineering applications. Although studies have examined repairing spinal cord injury with polyethylene glycol, these compelling findings have not been recently reviewed or evaluated as a whole. Thus, we her...

Spinal cord injury results in significant mortality and morbidity, lifestyle changes, and difficult rehabilitation. Treatment of spinal cord injury is challenging because the spinal cord is both complex to treat acutely and difficult to regenerate. Nanomaterials can be used to provide effective treatments; their unique properties can facilitate drug delivery to the injury site, enact as neuropr...

Impaired respiratory function is a common and devastating consequence of cervical spinal cord injury. Accordingly, the development safe effective treatments to restore breathing critical. Acute intermittent hypoxia has emerged as promising therapeutic strategy treat insufficiency in individuals with Since original report by Bach Mitchell (1996) concerning long-term facilitation phrenic motor ou...

background & importance: acute autonomic system impairment can be dangerous and life-threatening, and a clinician should be aware of its occurrence possibility. according to the anatomy of this system, spinal cord lesions could disturb its function. there are many reports of autonomic dysreflexia in spinal cord i njuries especially spinal cord trauma. case presentation: a 28 year-old man with a...

Spinal cord infarction is an uncommon disease and as such is often a diagnostic challenge for clinicians. It can vary in its onset, severity, outcome, and recovery from patient to patient. Treatment options for this relatively rare condition also remain elusive. Current consensus recommendations are antiplatelet therapy and the symptomatic management of associated complications such as parapleg...

Seven patients with acute central cervical spinal cord injury were operated upon during the subacute stages following injury, when their condition had improved and become stable for seven to ten days. Myelography in each case showed significant anterior compression of the spinal cord. The rapid improvement in function following the operation in these patients was gratifying and emphasizes the p...

Traumatic injury to the central nervous system results in the disruption of the blood brain/spinal barrier, followed by the invasion of cells and other components of the immune system that can aggravate injury and affect subsequent repair and regeneration. Although studies of chronic neuroinflammation in the injured spinal cord of animals are clinically relevant to most patients living with tra...

Background & Importance: Acute autonomic system impairment can be dangerous and life-threatening, and a clinician should be aware of its occurrence possibility. According to the anatomy of this system, spinal cord lesions could disturb its function. There are many reports of autonomic dysreflexia in spinal cord i njuries especially spinal cord trauma. Case Presentation: A 28 year-o...

Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number of oligodendrocytes progressively reduced within 24 h after injury. Administration of oligodendrocyte-like cells (OLCs) into the lesion area is one of the approaches to coun...

BACKGROUND AND IMPORTANCE A porous bioresorbable polymer scaffold has previously been tested in preclinical animal models of spinal cord contusion injury to promote appositional healing, spare white matter, decrease posttraumatic cysts, and normalize intraparenchymal tissue pressure. This is the first report of its human implantation in a spinal cord injury patient during a pilot study testing ...