Background Individuals with Down syndrome (DS) have a genetic predisposition for amyloid-β (Aβ) overproduction and earlier onset of Aβ deposits compared to sporadic late-onset Alzheimer’s disease (AD). Positron emission tomography (PET) Pittsburgh Compound-B (PiB) detects fibrillar pathology in living people DS AD, but its relationship heterogeneous forms aggregated within amyloid is not well u...

Topical or oral azole antifungals are commonly used in canine atopic dermatitis (AD), as the lipophilic yeast Malassezia pachydermatis exacerbates canine AD. To examine whether canine AD lesions harbor azole-resistant M. pachydermatis isolates in East Asia, we investigated the in vitro susceptibility of M. pachydermatis isolates to ketoconazole (KTZ) and itraconazole (ITZ) obtained from AD lesi...

Alzheimer's disease (AD) is one of the most well-known neurodegenerative diseases and explains 50-60% of dementia in patients. The prevalence rate of AD is positively correlated with age and AD affects ≥ 40% of those over 85 years old. The major AD therapeutics available on the market are acetylcholinesterase inhibitors, such as tacrine and donepezil. New therapeutic agents that can block the d...

AD (Alzheimer’s disease) is a neurodegenerative disorder characterized by self-assembly and amyloid formation of the 39–43 residue long Aβ (amyloid-β)-peptide. The most abundant species, Aβ(1–40) and Aβ(1–42), are both present within senile plaques, but Aβ(1–42) peptides are considerably more prone to selfaggregation and are also essential for the development of AD. To understand the molecular ...

Studies of plasma amyloid-β (Aβ) levels as potential biomarkers for incident Alzheimer's disease (AD) have yielded contradictory results. We explored the associations between plasma Aβ(40), Aβ(42), and truncated Aβ levels, and prognosis of dementia in participants of the prospective 3-City Study. 120 aged individuals diagnosed with 2-year incident dementia were followed up for seven years. The ...

Amyloid protein can damage nerve cells through a variety of biological mechanisms including oxidative stress, alterations in calcium homeostasis, and proapoptosis. Edaravone, a potent free radical scavenger possessing antioxidant effects, has been proved neuroprotective effect in stroke patients. The current study aimed to investigate the effects of EDA in an Aβ-induced rat model of AD, by stud...

The brains of Alzheimer’s disease (AD) patients have large numbers of plaques that contain amyloid beta (Ab) peptides which are believed to play a pivotal role in AD pathology. Several lines of evidence have established the inhibitory role of Ab peptides on hippocampal memory encoding, a process that relies heavily on aamino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor function....

Information on the dynamic evolution of humic acid (HA) from anaerobic digestate and potential HA serving as an effective agent for remedying heavy metals is rather scarce. This study monitored structure functional groups metal-binding abilities during chicken manure corn stover digestion (AD) processes. Higher increases in aromatic (41–66%) oxygen-containing (37–45%) were observed AD stover, r...

Both caloric restriction (CR) and low-protein, high-carbohydrate (LPHC) ad-libitum-fed diets increase lifespan and improve metabolic parameters such as insulin, glucose, and blood lipids. Severe CR, however, is unsustainable for most people; therefore, it is important to determine whether manipulating macronutrient ratios in ad-libitum-fed conditions can generate similar health outcomes. We pre...

The coexistence of atopic dermatitis (AD) and psoriasis has been not impossible, because their respective immunological situations involve distinct reactions. Recently, there are some reports of comorbidity of AD and psoriasis. Here we present the case of a patient with AD who developed psoriasis. A 43-year-old female developed AD, and new erythema has increased over 40 years. The results of sk...