The title compound, C(18)H(33)NO(3), was prepared according to a highly diastereoselective hydrogenation procedure from 3,5,7-triallyl-1-aza-adamantane-4,6,10-trione. The crystal structure of the title compound contains two crystallographically independent mol-ecules (Z' = 2), which are linked by inter-molecular hydrogen bonding into chains. In contrast to the aza-adamantanones, the aza-adamant...

In this report we present a polyketal, termed pADK, which has adamantane groups embedded in its backbone, and degrades into neutral excretable compounds. pADK was synthesized via click chemistry and had a MW of 49 472 and a PDI of 1.74. We demonstrate here that pADK can increase the transfection efficiency of CD1800 (PEI of 1800 modified β-cyclodextrin) 60 fold, yet cause no increase in toxicity.

In the title compound, C(23)H(26)O, the adamantane cage consists of three fused cyclo-hexane rings in classical chair conformations with absolute values of the C-C-C angles in the range 106.57 (11)-111.56 (12)°. The dihedral angle between the two phenyl rings is 81.38 (4)°. Although a hy-droxy group is present as a conceivable donor, no hydrogen bonds are observed in the crystal structure.

ABSTRACT Advances in Nuclear Magnetic Resonance (NMR) spectroscopy is a cornerstone structure elucidation of polycyclic 'cage' scaffolds. Due to the compactness these compounds, much overlap, as well unique through-space and bond NMR interactions are frequently observed. This review serves guide for future derivatives by providing some typical relevant aspects characteristic trends, substituent...