Increased expression of chromosomal genes for resistance-nodulation-cell division (RND)-type efflux systems plays a major role in the multidrug resistance (MDR) of Acinetobacter baumannii. However, the relative contributions of the three most prevalent pumps, AdeABC, AdeFGH, and AdeIJK, have not been evaluated in clinical settings. We have screened 14 MDR clinical isolates shown to be distinct ...

Over the past 20 years, psychoneuroimmunological research has produced a large body of evidence that challenges the historically dominant view that the immune system operates in an autonomous manner independent of other physiological systems. Today, there is little doubt that the brain and the immune system are intimately linked and capable of reciprocal communication (Ader et al. 1991). Despit...

demonstrated that stress may modify the immune activity, making the host more susceptible to the development of neoplasic processes (Ben-Eliyahu, Yirmiya, Liebeskind, Taylor, & Gale, 1991; Kiecolt-Glaser & Glaser, 1999; Moynihan & Ader, 1996; Thomas, Pandey, Ramdas, & Nair, 2002). One method of studying this question has been to use animal models of social stress, which due to their ethological...

Richey, Joyce M., Marilyn Ader, Donna Moore, and Richard N. Bergman. Angiotensin II induces insulin resistance independent of changes in interstitial insulin. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E920–E926, 1999.—We set out to examine whether angiotensin-driven hypertension can alter insulin action and whether these changes are reflected as changes in interstitial insulin (the signal to...

Background: This study aimed to evaluate the role of efflux pump regulator and OXA-23 genes in imipenem resistance Acinetobacter baumannii strains isolated from hospitalized patients in Tehran, Iran. Methods: This study was conducted on 60 A. baumannii isolates collected from pa...

Tigecycline is regarded as a last-resort treatment for multidrug-resistant Acinetobacter baumannii. However, tigecycline resistance in A. baumannii has increased worldwide. In this study, we investigated heteroresistance isolates from South Korea. Antibiotic susceptibility testing was performed on 323 nonduplicated isolates. Among 260 and 37 tigecycline-susceptible -intermediate-resistant isola...

I. Effects of Reserpine and Hydralazine on Carotid and Splanchnic Nerve Activity and Blood Pressure. A. S. Dontas 1 II. Action and Metabolism of Chiorpromazine Sulfoxide in Man. John C. Davidson, Luther L. Terry and Albert Sjoerdsma 8 III. Differentiation Between Receptors for Serotonin and Tryptamine by Means of the Exquisite Specificity of Antimetabolites. D. W. Woolley andE.Shaw 13 IV. A Qua...

GPU computing is expected to play an integral part in all modern Exascale supercomputers. It also that higher order Godunov schemes will make up about a significant fraction of the application mix on such is, therefore, very important prepare community users for hyperbolic PDEs this emerging opportunity. Not every algorithm used space-time update solution take well GPUs. However, we identify sm...