asthma is considered as a chronic inflammatory airway disease and defined as increased tracheobronchial responsiveness to variety of stimuli. edema and inflammatory cell infiltration in airway is observed in the asthmatic patients. one of the essential changes in inflammation is adhesion of leukocyte to endothelium and transmigration of leukocytes to the sites of inflammation. unfortunately, li...

objectives: postsurgical adhesion is one of the common complications after surgery. some anti-adhesion barriers are commercially available which are not customary used by physicians as much as expected because of ineffectiveness. recently, nanofibers have been introduced as anti-adhesion barriers with the potential of drug delivery. in the light of role of inflammation and oxidative stress in a...

  Occurrence of adhesions after pelvic and abdominal surgery is a well known problem. Previous surgical procedures are by far the most common cause of intra abdominal a adhesion. In over  10℅ of infertile women, adhesion formation is the main cause of their problem. Moreover postoperative adhesions are the most common cause of intestinal obstruction in the Western world. Although the cause of ...

During surgery to suture injured tissue, friction occurs at the interface between tissue and suture, which often causes serious “secondary trauma” fragile can lead inflammation infection. In article number 2001686, Kwanwoo Shin co-workers develope a novel surgical system that accelerates wound healing. The presence of fibronectin fibrils on engineered sutures improves cell migration adhesion in...

The adhesion of cells is mediated by receptors and ligands anchored in apposing membranes. A central question is how to characterize the binding affinity of these membrane-anchored molecules. For soluble molecules, the binding affinity is typically quantified by the binding equilibrium constant K3D in the linear relation [RL] = K3D[R][L] between the volume concentration [RL] of bound complexes ...

Objectives-  To evaluate radiographic changes and macroscopic findings in handsewn laparoscopic gastrojejunostomy in dogs. Study Design-Elective experimental study Animals-Eighteen mix-breed healthy male and female dogs. Methods-Animals were divided in two equal groups randomly. Two layers handsewn laparoscopic side to side gastrojejunostomy was performed in the control group and one laye...

The adhesion G protein-coupled receptors (GPCRs) are a distinct family of more than 30 receptors in vertebrate genomes. These receptors have been shown to play pivotal roles in a diverse range of biological functions and are characterized by extremely large N termini featuring various adhesion domains capable of mediating cell-cell and cell-matrix interactions. The adhesion GPCR N termini also ...

BACKGROUND Alpha-hydroxy acids such as glycolic acid (GA) and lactic acid (LA), are used in cosmetic patches. The important fact in cosmetic patches is its suitable adhesion and peel properties. AIM The objective of this study was to prepare LA- and GA-containing cosmetic patches and evaluate in-vitro/in-vivo correlation of adhesion properties. METHODS Pressure-sensitive adhesives with diff...

The cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A was shown to inhibit collagen-stimulated platelet aggregation and to interact with MG-63 osteosarcoma cells via integrin alpha2beta1 to inhibit adhesion to collagen I. In addition, we demonstrate by solid-phase binding assays that atrolysin A binds to collagen I and to vWF (von Willebrand factor) via exosites in the cyst...

Selectins are cell adhesion molecules that mediate capture and rolling adhesion of white blood cells to vascular walls, an essential component of the inflammatory response. Adhesion through L-selectin requires a hydrodynamic shear stress above a threshold level, a phenomenon known as the shear threshold effect. We have reported that the shear threshold effect can he re-created in cell-free syst...