Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

BACKGROUND This study was carried out to evaluate the nanoleakage of two types of nanofilled adhesive systems in Class V composite resin restorations. MATERIALS AND METHODS Totally 60 human premolars were randomly assigned to two groups (n = 30). Standardized round Class V cavities (enamel and dentin margins) were prepared. A total-etch (N-Bond total etch) (Ivoclar Vivadent) and self-etching ...

Aim: To evaluate the impact of a dual-cured adhesive system on in situ degree conversion (DC), bond strength (BS) and failure mode (FM) interfaces dentin cavities restored with bulk-fill resin composite. Methods: 4-mm-deep 3.1 C-factor were created 68 bovine incisors (n = 17 per group). The lightcured (Scotchbond™ Universal) or (Adper™ Scotchbond™ Multi-purpose Plus) was applied to cavities, wh...

OBJECTIVES The purpose of this study was to investigate the relationship between dentine shear bond strength, using data from experiments performed according to a standard protocol, and the absolute humidity for a new, fourth generation dentine adhesive system. METHODS Results of seven recently performed adhesion experiments using the same protocol and product were analysed. Groups of 10 huma...

The work described here is an uHrasonies based experimental study which aims to address the lack of a reliable technique for detecting strength loss in adhesive joints after exposure to hot wet environments. This is manifested as a change in the failure mode of an adhesive system from a cohesive failure in the as-made condition, that is failure through the adhesive, to an adhesive failure, fail...

Mussel-inspired adhesive hydrogels represent innovative candidate medical sealants or glues. In the present work, we describe an enzyme-degradable mussel-inspired adhesive hydrogel formulation, achieved by incorporating minimal elastase substrate peptide Ala-Ala into the branched poly(ethylene glycol) (PEG) macromonomer structure. The system takes advantage of neutrophil elastase expression upr...