OBJECTIVES To assess durability of visual and anatomic gains with 2.0 mg ranibizumab in recalcitrant neovascular age-related macular degeneration (AMD). METHODS Phase I-II trial of 88 patients with recalcitrant neovascular AMD treated as needed every 4 (cohort A) or 6 weeks (cohort B) following three monthly doses. ETDRS refraction and spectral-domain OCT-guided as-needed re-treatments. RES...

Neuropsychological baseline testing is commonplace in the assessment of concussion; however, claims of "sandbagging" the baseline have led neuropsychologists to ask to what extent athletes can perform intentionally poorly on baseline testing without reaching threshold on the test validity indicators. Seventy-five undergraduate athletes were re-administered the ImPACT neurocognitive battery, whi...

A new Greenland Ice Core Chronology (GICC05) based on multi-parameter counting of annual layers has been obtained for the last 42 ka. Here we compare the glacial part of the new time scale, which is based entirely on records from the NorthGRIP ice core, to existing time scales and reference horizons covering the same period. These include the GRIP and NorthGRIP modelled time scales, the MeeseSo...

OBJECTIVES Our aim was to estimate the national prevalence of overweight and obesity in Swiss primary schoolchildren and to determine if adiposity is increasing in this age group. METHODS We used a cross-sectional, 3-stage, probability-proportionate-to-size cluster sampling of primary schools throughout Switzerland to obtain a representative national sample of 6-12 year old children (n = 2431...

OBJECTIVES The assessment of early sucking by preterm infants provides information on the ability of these infants to efficiently and safely receive nutrients via an oral route (oral feeding). To analyze the application and reliability of an instrument in assessing non-nutritive sucking that indicates a capacity for oral feeding in the routine care of different neonatal units. METHODS A multi...

The nucleotide sequence coding for the nonstructural proteins of Semliki Forest virus has been determined from cDNA clones. The total length of this region is 7381 nucleotides, it contains an open reading frame starting at position 86 and ending at an UAA stop codon at position 7379-7381. This open reading frame codes for a 2431 amino acids long polyprotein, from which the individual nonstructu...

Background: The adiposity rebound is the second rise in body mass index that occurs between 3 and 7 years. An early age at adiposity rebound is known to be a risk factor for later obesity. The aim here is to clarify the connection between the age at rebound and the corresponding pattern of body mass index change, in centile terms, so as to better understand its ability to predict later fatness....