Both Brugada Syndrome (BrS) and progressive cardiac conduction defect (PCCD) are associated respectively with diffuse and discrete alterations in conduction pathways affected by ageing and sex. This study assessed for contributions of such processes to the mechanism of conduction changes in Scn5a(+/-) and WT hearts stratified by age (3 and 12 months) and sex. In vivo electrocardiographic chest-...

Dr. G.E. Piérard, Department of Dermatopathology, CHU Sart-Tilman, B-4000 Liège (Belgium) The unprecedented size of the elderly population com Chronologic ageing Genetic ageing Photoageing Behavioral ageing Catabolic ageing, Type Endocrine ageing Gravitational aseins pels research to understand the physiological changes related to skin ageing. A classical, yet oversimplified classification of c...

To date five different theories compete in explaining the biological mechanisms of senescence or ageing in invertebrates. Physiological, genetical, and environmental mechanisms form the image of ageing in individuals and groups. Social insects, especially the honeybee Apis mellifera, present exceptional model systems to study developmentally related ageing. The extremely high phenotypic plastic...

OBJECTIVES This study aimed to develop and pilot the Alzheimer's Disease and Ageing Perception Scale (ADAPS), examine theory-consistent differences and convergent validity, and identify misconceptions of the cognitive effects of ageing and mild Alzheimer's disease (AD). METHOD After piloting a large pool of items with a panel of ageing and dementia experts (n = 6), an item analysis yielded a ...

Given the duration of ageing in humans, cell culture studies are a promising approach to the study of human ageing. It is reasonable to assume that human ageing has, at least partly, a cellular origin. The question is how we can replicate in vitro the age-related changes that occur in human cells in vivo. In this review, widely used models for studying ageing in cell culture, such as Hayflick's...

The aim of this work was to provide an overview of the genetics of human ageing to gain novel insights about the mechanisms involved. By incorporating findings from model organisms to humans, such as mutations that either delay or accelerate ageing in mice, we constructed the gene networks previously related to ageing: namely, the network related to DNA metabolism and the network involving the ...