Two split-brain patients, a patient with callosal agenesis, and 6 age-matched control participants were tested on a bimanual force production task. The participants produced isometric responses with their index fingers, attempting to match the target force specified by a visual stimulus. On unimanual trials, the stimuli were presented in either the left or right visual field and the response wa...

Transient reversible lesions (TSL) in the splenium of corpus callosum are often found on MR imaging, with the patients recovering without any neurologic defects after mild clinical courses (1). MR imaging have shown restricted diffusion in the central portion of splenium of corpus callosum (2). Many studies have presented the causing factors of TSL, defining hypothetic pathogenesis. These lesio...

Recently, a growing body of data has revealed that beyond a dysfunction of connectivity among different brain areas in schizophrenia patients (SCZ), there is also an abnormal asymmetry of functional connectivity compared with healthy subjects. The loss of the cerebral torque and the abnormalities of gyrification, with an increased or more complex cortical folding in the right hemisphere may pro...

This paper investigates the extent to which the shape of one of the brain structures, the Corpus Callosum, is correlated to (or moreover, can predict) the presence of dyslexia. A statistical shape analysis reveals differences in CC shape between a group of 20 normal subjects and a group of 20 dyslexic subjects. Moreover, a classification system based on the length of the isthmus region can accu...

Handedness and brain asymmetry have been linked to neurodevelopmental disorders such as dyslexia and schizophrenia. The genetic nature of this correlation is not understood. Recent discoveries have shown handedness is determined in part by the biological pathways that establish left/right (LR) body asymmetry during development. Cilia play a key role in this process, and candidate genes for dysl...

We examined the effects of visual deprivation at birth on the development of the corpus callosum in a large group of congenitally blind individuals. We acquired high-resolution T1-weighted MRI scans in 28 congenitally blind and 28 normal sighted subjects matched for age and gender. There was no overall group effect of visual deprivation on the total surface area of the corpus callosum. However,...

Purpose. A new technique for analyzing the morphology of the corpus callo-sum is presented, and it is applied to a group of elderly subjects. Methods. The proposed approach normalizes subject data into the Talairach space using an elastic deformation transformation. The properties of this transformation are used as a quantitative description of the callosal shape with respect to the Talairach a...