The modern Western diet is rich in advanced glycation end products (AGEs). We have previously shown an association between dietary AGEs and markers of inflammation and oxidative stress in a population of end stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD). In the current pilot study we explored the effects of dietary AGEs on the gut bacterial microbiota composition in si...

The reactive advanced glycation end product (AGE) precursor methylglyoxal (MGO) and MGO-derived AGEs are associated with diabetic vascular complications and also with an increase in oxidative stress. Glyoxalase-I (GLO-I) transgenic rats were used to explore whether overexpression of this MGO detoxifying enzyme reduces levels of AGEs and oxidative stress in a rat model of diabetes. Rats were mad...

Our ability to determine stellar ages from measurements of stellar rotation, hinges on how well we can measure the dependence of rotation on age for stars of different masses. Rotation periods for stars in open clusters are essential to determine the relations between stellar age, rotation, and mass (color). Until recently, ambiguities in v sin i data and lack of cluster membership information,...

Few studies have explored the development of response selection processes in children in the case of object manipulation. In the current research, we studied the end-state comfort effect, the tendency to ensure a comfortable position at the end rather than at the beginning of simple object manipulation tasks. We used two versions of the unimanual bar transport task. In Experiment 1, only 10-yea...

A wide range of observational and theoretical arguments suggest that the universe experienced a period of heating and metal enrichment, most likely from starbursting dwarf galaxies. Using a hydrodynamic simulation we have conducted a detailed theoretical investigation of this epoch at the end of the cosmological “dark ages”. Outflows strip baryons from pre-viralized halos with total masses ∼ <1...

Introduction. Professionals who assess early childhood development highly benefit from reliable development screening measures. The Ages & Stages Questionnaire was adapted Brazil in 2010 and named ASQ-BR. Modifications in some items were required to improve the instrument's psychometric properties. The present study modified the ASQ-BR to verify if those changes increase its characteristics. Me...

OBJECTIVE To examine the longitudinal association between plasma total cholesterol and triglyceride levels and incident dementia. METHODS Neuropsychiatric, anthropometric, laboratory, and other assessments were conducted for 392 participants of a 1901 to 1902 birth cohort first examined at age 70. Follow-up examinations were at ages 75, 79, 81, 83, 85, and 88. Information on those lost to fol...