BACKGROUND Previous studies reported that old adults, relative to young adults, showed improvement of emotional stability and increased experiences of positive affects. METHODS In order to better understand the neural underpinnings behind the aging-related enhancement of positive affects, it is necessary to investigate whether old and young adults differ in the threshold of eliciting positive...

Healthy aging is marked by declines in a variety of cognitive and motor abilities. A better understanding of the aging brain may aid in elucidating the neural substrates of these behavioral effects. Investigations of resting state functional brain connectivity have provided insights into pathology, and to some degree, healthy aging. Given the role of the cerebellum in both motor and cognitive b...

Single-tooth implants are an increasingly popular method for replacing single teeth. While the effects of growth on implants in children have been well documented, the changes that occur in adults have not been studied with respect to single-tooth implants. It has been assumed that adults are stable and do not change; however, research in the last few years has indicated that adults do change w...

Aging is usually accompanied by alterations of cognitive control functions such as conflict processing. Recent research suggests that aging effects on cognitive control seem to vary with degree and source of conflict, and conflict specific aging effects on performance measures as well as neural activation patterns have been shown. However, there is sparse information whether and how aging affec...

Aging is associated with a progressive decline in immune function (immunosenescence) resulting in an increased susceptibility to viral and bacterial infections. Here we show reduced expression of Toll-like receptor 1 (TLR1) in polymorphonuclear leukocytes (PMN) and an underlying age-dependent deficiency in PMN bioenergetics. In older (>65 years) adults, stimulation through TLR1 led to lower act...

Anticorrelation between the default and dorsal attention networks is a central feature of human functional brain organization. Hallmarks of aging include impaired default network modulation and declining medial temporal lobe (MTL) function. However, it remains unclear if this anticorrelation is preserved into older adulthood during task performance, or how this is related to the intrinsic archi...

Both normal aging and Alzheimer's disease (AD) have been associated with a reduction in functional brain connectivity. It is unknown how connectivity patterns due to aging and AD compare. Here, we investigate functional brain connectivity in 12 young adults (mean age 22.8 ± 2.8), 12 older adults (mean age 73.1 ± 5.2) and 12 AD patients (mean age 74.0 ± 5.2; mean MMSE 22.3 ± 2.5). Participants w...

Abstract With the rapid demographic changes, it is predicted that every fifth person in U.S. will be age 65 or older next decade. The quality of life and successful aging adults, who now live longer, an important research area from societal public health perspectives. Rowe Kahn (1997) defined as having a low probability disease disability, high cognitive physical functioning, active engagement ...

The aim of the present article is to offer a broad overview usual methods and dominant theories in field, order make unfamiliar readers more aware current state art this domain show how it can support future investigation on learning adaptation older adults. As our understanding aging process closely linked used investigate it, first part devoted field their potential limitations. It also highl...

Arguably, active travel (AT) is important for aging. Using data from the Travel Survey of Xiamen Residents 2015 and geodata, this study develops a set multilevel regression models to scrutinize effect neighborhood-level built environment on three AT outcomes (daily propensity, frequency, time) older adults aged 60 years or above in Xiamen, China. Its results show that truly shapes behavior adul...