The study aims to analyze the influence of complex service factors on ravelling resistance performance for large-void asphalt pavements by carrying out tests environmental and vehicle factors, conducting ultraviolet aging, freeze–thaw cycles, as well speed simulated with Rotating Surface Abrasion Test, tests, traffic volume making a correlation analysis between Cantabro test Test. result shows ...

Since in vitro methods (2D and 3D) used for the preclinical testing of candidate anti-aging compounds mimic complexity human skin aging unsatisfactorily, we wished to develop an ex vivo assay interrogating key aging-read outs healthy skin. Healthy, full-thickness biopsies (2 males, 4x females; 22 - 77 years) were organ-cultured serum-free, supplemented medium 3 days presence/absence recognized ...

Anti-vibration gloves have been used in real workplaces to reduce vibration transmitted through hand-held power tools to the hand. Generally materials used for vibration attenuation in gloves are resilient materials composed of certain synthetic and/or composite polymers. The mechanical characteristics of the resilient materials used in anti-vibration gloves are prone to be influenced by enviro...

Aging is characterized by progressive loss of cellular function and integrity. It has been thought to be driven by stochastic molecular damage. However, genetic and environmental maneuvers enhancing mitochondrial function or inhibiting glycolysis extend lifespan and promote healthy aging in many species. In post-fertile Caenorhabditis elegans, a progressive decline in phosphoenolpyruvate carbox...

With the increasing need for highly secure systems, Physical Unclonable Functions (PUFs) have emerged within the last decade. Ordering based Ring Oscillator (RO) PUFs are one of the best performing structures with their robustness and suitability to FPGA implementations. Even though the performance of the ordering based RO-PUFs have been analyzed in detail, effects of aging have not been studie...

Bilinguals use two different language systems to mediate not only social communication, but also cognitive processes. Potential differences between bilinguals and monolinguals in task-solving strategies and patterns of cognitive decline during normal and abnormal aging have been suggested. Main contribution A research review of the area suggests that normal aging is associated with increased ...

To examine transcriptional alterations associated with aging in skeletal muscle and the heart, we and others have used DNA microarrays to compare the gene expression profile of young and old animals. Aging results in a differential gene expression pattern specific to each tissue, and most alterations can be completely or partially prevented by caloric restriction (CR) in both heart and skeletal...

INTRODUCTION Aging leads to a decline in the functional competence of human bodies as well as to degenerative changes in connective tissues such as tendons. Aging tendons lose the integrity of their matrix and mechanical strength. However, the precise cellular mechanisms responsible for the detrimental effects of aging on tendons are unknown. We recently identified tendon stem cells (TSCs) in r...

Normal temperature tensile and fatigue tests were adopted to test the mechanical performance and fatigue life of 2524 aluminum alloy under the three states of T3, artificial aging, and creep aging, and scanning electron microscope and transmission electron microscope were also used to observe the fatigue fracture morphology and aging precipitation features of the alloy under the above three sta...

The geroscience hypothesis posits that therapies to slow biological processes of aging can prevent disease and extend healthy years of life. To test such "gero-protective" therapies in humans, outcome measures are needed that can assess extension of disease-free lifespan. This need has spurred development of different methods to quantify biological aging. But different methods have not been sys...