The activity of alanine-cr-ketoglutarate transaminase (n-alanine :2-oxoglutarate aminotransferase, EC 2.6.1.2) is increased markedly in the livers of diabetic or fasted rats (1). The induction of this enzyme also occurs when either intact or adrenalectomized rats are fed diets high in protein or given corticosteroid injections (24). The adaptive response of this enzyme in glucocorticoid-sensiti...

BACKGROUND Inflammatory bowel diseases (IBD) are characterized by chronic relapsing inflammation of the gastrointestinal tract and encompass Crohn's disease and ulcerative colitis. IBD are often associated with extraintestinal manifestations affecting multiple organs including the liver. Increased levels of serum aminotransferases, possibly related to nonalcoholic fatty liver disease, constitut...

The general performance of the Technicon AutoAnalyzer II method for the routine estimation of serum aspartate and alanine transaminase has been assessed and compared with that of the LKB reaction rate analyser. The results of the two methods correlate, there is little difference in precision, and running costs are comparable. Some of the relative advantages of the two types of analysis are disc...

In mycobacteria, d-alanine is an essential precursor for peptidoglycan biosynthesis. The only confirmed enzymatic pathway to form d-alanine is through the racemization of l-alanine by alanine racemase (Alr, EC 5.1.1.1). Nevertheless, the essentiality of Alr in Mycobacterium tuberculosis and Mycobacterium smegmatis for cell survivability in the absence of d-alanine has been a point of controvers...

The present study aimed to synthesize new metal complexes of diacetylmonoxime-N(4)antipyrinylthiosemicarbazone ligand and evaluate their antitumor activity. New with ferric, cobalt, nickel copper ions were prepared. Elemental, 1H Nuclear magnetic resonance, Mass spectroscopy, Electron paramagnetic Fourier Transform Infrared Spectroscopy, Ultraviolet–visible thermal gravimetric analysis used cha...

pregnancy, labour, and delivery. He was initially fed orally on a standard infant formula, but feeding became increasingly difficult and he failed to thrive. At 6 weeks of age, he was admitted to hospital, where he continued to gain weight poorly despite numerous feed changes. Nasogastric feeding was therefore started at 10 weeks of age. Investigations showed intermittent neutropenia (the lowes...

The resolution-of-the-identity (RI) approximation has placed the onus of the cost of a second-order Moller-Plesset (MP2) calculation on the underlying self-consistent field (SCF) calculation for many moderately sized molecules. A dual-basis approach to the SCF calculation, based on previous methods demonstrated for density functional theory, is combined with RI-MP2 calculations, and small basis...

We present a method for determining the average transition path and the free energy along this path in the space of selected collective variables. The formalism is based upon a history-dependent bias along a flexible path variable within the metadynamics framework but with a trivial scaling of the cost with the number of collective variables. Controlling the sampling of the orthogonal modes rec...