نتایج جستجو برای: alarmins
تعداد نتایج: 2072 فیلتر نتایج به سال:
1Faculty of Computing and Information Technology in Rabigh, King Abdul Aziz University, Jeddah, Saudi Arabia 2Department of Computer Science, Abdul Wali Khan University Mardan, Pakistan 3Department of Computer Sciences, South China University of Technology, Guangzhou, China 4School of Computer Science and Software Engineering, East China Normal University, Shanghai, China 5Department of Mathema...
Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions.
Hyporesponsiveness by phagocytes is a well-known phenomenon in sepsis that is frequently induced by low-dose endotoxin stimulation of Toll-like receptor 4 (TLR4) but can also be found under sterile inflammatory conditions. We now demonstrate that the endogenous alarmins MRP8 and MRP14 induce phagocyte hyporesponsiveness via chromatin modifications in a TLR4-dependent manner that results in enha...
Introduction During evolution, multicellular organisms have developed mechanisms to counteract life-threatening events, such as infections and tissue injury, as well as to restore tissue homeostasis. These mechanisms are called ‘the inflammatory response’. To initiate an appropriate inflammatory response, organisms have developed ways to recognize potentially life-threatening events. Danger sig...
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