The evolution of promiscuous halide methyltransferases enables the enzymatic synthesis S-adenosyl-l-methionine analogues from alkyl iodides and S-adenosyl-l-homocysteine. This facilitates with groups larger than methyl groups, which can readily be used by methyltransferases. These processes provide access to diverse alkylated products altered bioactivities, expanding synthetic potential We expe...

Stereocontrolled Mn-mediated radical addition of alkyl iodides to chiral N-acylhydrazones enables strategic C-C bond disconnection of chiral amines. This strategy was examined in the context of a total synthesis of quinine, generating new findings of functional group compatibility leading to a revised strategy. Completion of a formal synthesis of quinine is presented, validating the application...

The influence of copper promoters and reaction conditions on the formation of alcohols byproducts of a common Fischer-Tropsch synthesis used iron-based catalysts were investigated. A good compromise of 28%Cu/FeKLaSiO2 can lead to the optimization of an improved Fischer-Tropsch catalyst. The product distribution shifts towards hydrocarbons with increasing the reaction temperature, while pressure...

Simple alcohols such as methanol and ethanol, are organic chemicals that can be used to store energy, which an alternative fossil fuels. Each alcohol has at least one hydroxyl group attached a carbon atom of alkyl group. They considered derivatives water in the hydrogen atoms is replaced by In this work, we determined thermodynamic structural properties two dimensional water-alcohol mixtures us...

The development of a mild and general method for the alkylation of amides with relatively unreactive alkyl halides (i.e., poor substrates for SN2 reactions) is an ongoing challenge in organic synthesis. We describe herein a versatile transition-metal-catalyzed approach: in particular, a photoinduced, copper-catalyzed monoalkylation of primary amides. A broad array of alkyl and aryl amides (as w...

A simple method was invented to achieve a high yield of cellulosic biomass-derived alkyl levulinates, which have the potential to be alternative fuel additives. Alkyl levulinates, such as butyl-, pentyl-, and hexyl levulinates, were produced using single-step acid-catalyzed solvolysis of cellulosic biomass without the use of elevated pressure. Reactions were performed by refluxing alcohols such...