BACKGROUND Both gastrectomy (GX) and ovariectomy (OVX) induce osteopenia in man and experimental animals. The present study addresses the question--can alendronate, estrogen or parathyroid hormone (PTH) be used to treat established GX- or OVX -evoked osteopenia? METHODS Rats were GX-, OVX- or SHAM-operated 8 weeks before starting the treatment with drugs. Each group was then treated for 8 wee...

OBJECTIVES  To determine the skeletal safety and efficacy of long term (≥10 years) alendronate use in patients with osteoporosis. DESIGN  Open register based cohort study containing two nested case control studies. SETTING  Nationwide study of population of Denmark. PARTICIPANTS  61 990 men and women aged 50-94 at the start of treatment, who had not previously taken alendronate, 1996-2007...

Purpose: Dead space management has a crucial role in the treatment of osteomyelitis. Bisphosphonates effectively inhibit bone resorption. Recently bisphosphonates started to promise a role in improving the long term duration of joint arthroplasties by means of prevention of aseptic loosening and osteolysis. Bone loss around implants are localized to a region immediately surrounding the implant ...

background: ankylosing spondylitis (as) is an inflammatory rheumatic disease that leads to a progressive ankylosis of vertebras and ossification of paravertebral ligaments. bone loss and osteoporosis are amongst the important complications of as, treatment of which is a challenging issue. objectives: this study aimed to clarify the effect of alendronate on the prevention of bone loss in patient...

Bisphosphonates are widely used anti-osteoporotic drugs targeting osteoclasts. They strongly inhibit bone resorption, but also reduce formation. This reduced formation is commonly ascribed to the mechanism maintaining resorption/formation balance during remodeling. The present study provides evidence for an additional where bisphosphonates actually impair onset of after resorption. based on mor...

mg/d alendronate sodium with calcium salts for 1 year. The patient consulted 3 days after the presentation of extremely painful ulcers on the oral mucosa, palate, tongue, and lower lip. Following careful questioning, the patient reported having allowed the alendronate tablet to dissolve in his mouth on one occasion several days previously because he was traveling. The second case was a 57-year-...

Osteoclastic resorption of bones plays a central role in both osteoporosis and bone metastasis. A reliable vitro assay that simulates osteoclastic vivo would significantly speed up the process developing effective therapeutic solutions for those diseases. Here, we reported development novel robust nanostructured calcium phosphate coating with unique functions on track-etched porous membrane by ...

OBJECTIVE The aim of this study was to create a new injectable bone graft substitute by combining the features of calcium phosphate and bisphosphonate as a composite bone graft to support bone healing and to evaluate the effect of alendronate to the bone healing process in an animal model. MATERIAL AND METHOD In this study, 24 New Zealand white rabbits were randomly divided into two groups: a...