The heterocyclic compounds are very important part of medicinal chemistry, among them it is worth to pay attention on derivatives of quinazoline. They have a broad spectrum of pharmacological activities like anticancer (1ñ3), anti-HIV (3), antitubercular (4), anti-inflammatory (5), anticonvulsant (6) and antihypertensive activity (7). The most recognized derivatives among quinazolines with anti...

A wide array of drugs are available for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH), but the evidence for the comparative effectiveness is controversial.The objective of this study is to evaluate the comparative effectiveness and safety of monodrug therapies for BPH.Data sources are MEDLINE, EMBASE, and the Cochrane Library.We included random...

In benign prostatic hyperplasia (BPH) there will be a sudden impact on overall quality of life of patient. This disease occurs normally at the age of 40 or above and also is associated with sexual dysfunction. Thus, there is a need of update on current medications of this disease. The presented review provides information on medications available for BPH. Phytotherapies with some improvements i...

PURPOSE We determined the effects of alpha-blockers and quinolone in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) classified by National Institute of Health (NIH) consensus group. MATERIALS AND METHODS Data from a total of 111 patients who were diagnosed with CP/CPPS between June 2010 and June 2012 were analyzed retrospectively. The patients were classified into gr...

OBJECTIVES To evaluate and compare anterior segment changes in patients taking alpha-1 (α1) blockers (tamsulosin, terazosin, doxazosin, alfuzosin) for benign prostatic hypertrophy, during drug intake and drug-free period, using ultrasound biomicroscopy (UBM). MATERIALS AND METHODS In this prospective study, UBM was done before and after pupil dilatation in 31 phakic eyes of 19 male patients t...

OBJECTIVE To review the existing evidence regarding the efficacy and safety of medical therapy for lower urinary tract symptoms (LUTS) indicative of benign prostatic hyperplasia (BPH). To assess randomised controlled trials investigating the six alpha-adrenergic receptor antagonists (alpha-blockers), prazosin, alfuzosin, indoramin, terazosin, doxazosin, and tamsulosin, that benefit patients by ...

PURPOSE We analyzed the prescriptions of alpha-blockers and phosphodiesterase 5 inhibitors (PDE5Is) in the urology department as well as in other departments of the general hospital. METHODS We investigated the frequency of prescription of alpha-blockers and PDE5Is from 3 general hospitals from January 1, 2007 to December 31, 2009. For alpha-blockers, data were collected from patients to whom...

Society for Sexual Medicine definition. IELT was measured by the patient and his partner using a stop watch. Treatment outcomes were evaluated by IELT, the Clinical Global Impression Change (CGIC groups: " better " or " much better " [B/MB], " slightly better " [SB], and " no change " [NC]), and PE profiles. Ejaculation-related problems were investigated and parameters included were anejaculati...