Background & Aims. Chronic pancreatitis (CP) is often associated with abdominal pain, which impairs quality of life. The aim of this prospective study was to clarify whether the use of a low-fat elemental diet (ED) is beneficial for managing pain in patients with CP. Methods. Seventeen CP patients with pain despite fat-restricted dietary and conventional medical treatments were enrolled in this...

Mammography is widely performed as a standardized procedure for breast cancer screening; however, women often feel some degree of pain during this procedure. Currently, there are limited options available for alleviating pain related to mammography. A non-medicinal approach to the alleviation of pain involves the effects of laughter on physical and psychological wellbeing. We therefore examined...

Tetrodotoxin (TTX), a blocker of sodium channels, exists in the pufferfish, amphibians, and octopus, originated endosymbiont-vibrio. Researches have confirmed that TTX affected action potential through regulation voltage-gated channels (VGSCs) ingestion inhibits nerve signal’s transmission, showing symptoms like rapid weakening paralysis muscles. Recent research shows TTX’s medical value as ana...

Background: Propofol gains popularity due to its smooth induction and rapid recovery. But one of side effects is pain during injection. So, the aim this study was compare efficacy tramadol lidocaine pretreatment for alleviation on propofol injection in our setting.
 Materials methods: 80 patients either sex (ASA grade I II, age 20-50 years) who underwent elective Surgery under general anae...

Cancer-related facial pain refractory to pharmacologic management or nondestructive means is a major indication for destructive pain surgery. Stereotactic mesencephalotomy can be a valuable procedure in the management of cancer pain involving the upper extremities or the face, with the assistance of magnetic resonance imaging (MRI) and electrophysiologic mapping. A 72-year-old man presented wit...

Neck pain is a common disorder affecting 57% of the German population 1 , and, combined with low back pain, it results in costs of nearly 3.3 billion euros 2 . A number of studies show moderate to good evidence that manual therapy may alleviate neck pain 3-7 . This analgesic effect may not only be explained by traditional approaches such as the Gate-Control-Theory 8 and reduced peripheral affer...

Methods. Lumbar intrathecal catheters were implanted in male Sprague–Dawley rats and a CCI model was established. Thermal and mechanical nociceptive thresholds were assessed with paw withdrawal latency (PWL) to radiant heat and von Frey filaments. The phosphorothioate-modified antisense ODNs to p65 subunit of NF-kB were administered intrathecally on each of five consecutive days post-CCI. Nucle...

Anti-inflammatory activity of resveratrol has been widely studied, while its beneficial effect on the management of neuropathic pain, a refractory chronic syndrome with pro-inflammation implicated in, is very little investigated. In the present study, the effects of different doses and various time window of administration of resveratrol were explored in a neuropathic mouse model of chronic con...

Pain in nonhuman animals is a difficult concept to identify and measure. This article briefly describes the consequences of pain in animals on the farm and explains the reasons for the minimal use of analgesics in farmed animals. Pain can have implications for both animal welfare and economics. The reasons for a low use of analgesics in farmed animals include the lack of recognition of animal p...