Umbilical cord blood (UCB) is increasingly used as a source of hematopoietic progenitor cells for allotransplantation. Donor-derived buffy coat cells are considered optimal treatment for leukemia relapses after transplantation of allogeneic bone marrow. Experience with relapses after UCB transplants are sparse. Here we report a girl who received an UCB transplant for chronic myeloid leukemia, r...

INTRODUCTION: Vascularized composite allotransplantation (VCA) offers superior functional recovery following devastating maxillofacial and upper limb injuries compared to traditional reconstructive techniques. Here, we evaluate the efficacy of a novel sub-normothermic (SN) ex-vivo perfusion strategy using hyper-oxygenated University of Wisconsin (UW) solution to mitigate reperfusion injury (RI)...

Vascularized composite tissue allotransplantation (VCA) offers treatment options of complex functional deficiencies that cannot be repaired with conventional reconstructive methods. VCAs consist of blocks of functional units comprising different tissue types such as skin, bone, muscle, nerves, blood vessels, tendons, ligaments and others, and are thus substantially different from the compositio...

Restoration of upper extremity function poses a unique surgical challenge. With considerations ranging from ensuring appropriate skeletal support and musculotendinous ligamentous anatomy, restoring adequate vascularity innervation, providing sufficient soft tissue coverage, injuries present diverse range reconstructive problems. Recent history has been marked by an expansion novel techniques fo...

J Thorac Cardiovasc Surg Hiroki Ueda and Yasuhiko Shimizu Yu Liu, Tatsuo Nakamura, Yasumichi Yamamoto, Kazuya Matsumoto, Takashi Sekine, graft by detergent treatment tracheal grafts can be reduced by removing the epithelium and mixed glands from the Immunosuppressant-free allotransplantation of the tracheaThe antigenicity of http://jtcs.ctsnetjournals.org/cgi/content/full/120/1/108 the World Wi...

J Thorac Cardiovasc Surg Nelson S. Yew, T. Mohanakumar and G. Alexander Patterson Hideki Itano, Bassem N. Mora, Wanjiang Zhang, Jon H. Ritter, Timothy J. McCarthy, allotransplantation Lipid-mediated ex vivo gene transfer of viral interleukin 10 in rat lung http://jtcs.ctsnetjournals.org/cgi/content/full/122/1/29 the World Wide Web at: The online version of this article, along with updated infor...

Cardiac allotransplantation is subject to a number of chronic complications that may limit graft survival. These include allograft coronary artery disease, renal dysfunction, hypertension, and malignancy, which are largely due to the immuno-modulatory and adverse effects of transplant medications. Reoperation for native allograft disease progression is a rarer phenomenon. We report a case of ao...

PURPOSE To investigate the reproducibility of the experimental model of face allotransplantation in rats in Brazil. METHODS Eighteen rats were operated, nine-nine donors recipients. Animals underwent transplantation of the left hemiface, with periorbital and scalp. Transplants were made from donor Wistar rats to recipients Lewis rats. Flaps were based on the common carotid artery and the exte...

Blockade of the CD154-CD40 co-stimulatory pathway with anti-CD154 mAbs has shown impressive efficacy in models of autoimmunity and allotransplantation. Clinical benefit was also demonstrated in systemic lupus erythematosus (SLE) and idiopathic thrombocytopenia patients with the humanized anti-CD154 mAb, 5C8 (hu5C8). However, thromboembolic complications that occurred during the course of the hu...