BACKGROUND The reduction of instrumental dead space is a recognized approach to preventing ventilation-induced lung injury in premature infants. However, there are no published data regarding the effectiveness of instrumental dead-space reduction in endotracheal tube (ETT) connectors. We tested the impact of the Y-piece/ETT connector pairs with reduced instrumental dead space on CO2 elimination...

ABSTRACT       The clinical manifestations of coronavirus disease 2019 (COVID-19)-associated pneumonia show a wide range variations. It ranges from mild hypoxemia without significant signs respiratory distress, to rapid clinically deteriorating course with severe hypoxemia. Unexplained hypoxemia, associated platypnea, triggers the possibility ventilation-perfusion (V/Q) mismatch, ranging intrap...

Background: The volume shrinkage of the alveolar ridge might be minimized by the ridge preservation stages and applied biomaterials, after tooth extraction. Objectives: The aim of this study is to compare alloplastic with allograft in terms of preservation and bone regeneration of the alveolar ridge after tooth extraction. Materials and Methods: This study clinically assessed this issue via the...

High-flow nasal cannula (HFNC) oxygen therapy has several physiological advantages over traditional oxygen therapy devices, including decreased nasopharyngeal resistance, washing out of the nasopharyngeal dead space, generation of positive pressure in the pharynx, increasing alveolar recruitment in the lungs, humidification of the airways, increased fraction of inspired oxygen and improved muco...

A prototype high-frequency ultrasonic nebulizer, coupled with a nebu lization chamber, has been designed specifically to overcome the problem of inefficient and unpredictable radioaerosol delivery. The objective was to reduce mean particle size, increase aerosol concentration, and minimize dead space. Thirty-nine patients were studied, including 15 patients in sig nificant respiratory distress....

AIM To examine the delivered volume during "high volume strategy" high frequency oscillation, used as rescue treatment in preterm infants; and to identify factors, other than frequency and oscillatory amplitude, influencing the magnitude of volume delivery. METHOD Twenty infants (median gestational age 29 weeks) were studied on 45 occasions. Two oscillator types were used (SensorMedics and SL...

Recently there has been growing interest in an alternative to conventional oxygen therapy: the heated, humidified high flow nasal cannula oxygen therapy (HFNC). A number of physiological effects have been described with HFNC: pharyngeal dead space washout, reduction of nasopharyngeal resistance, a positive expiratory pressure effect, an alveolar recruitment, greater humidification, more comfort...

background and aims . dentists administer thousands of local anesthetic injections every day. injection to a highly vascular area such as pterygomandibular space during an inferior alveolar nerve block has a high risk of intravascular needle entrance. accidental intravascular injection of local anesthetic agent with vasoconstrictor may result in cardiovascular and central nervous system toxicit...

The concept of genetic susceptibility factors predisposing cigarette smokers to develop emphysema stems from the clinical observation that only a fraction of smokers develop clinically significant chronic obstructive pulmonary disease. We investigated whether Smad3 knockout mice, which develop spontaneous air space enlargement after birth because of a defect in transforming growth factor-β (TGF...