نتایج جستجو برای: alveolar epithelial
تعداد نتایج: 195783 فیلتر نتایج به سال:
Exposure of human populations to chronically elevated levels of ambient particulate matter air pollution < 2.5 μm in diameter (PM(2.5)) has been associated with an increase in lung cancer incidence. Over 70% of lung cancer cell lines exhibit promoter methylation of the tumor suppressor p16, an epigenetic modification that reduces its expression. We exposed mice to concentrated ambient PM(2.5) v...
A carbon monoxide (CO)-intoxicated patient developed increased permeability-type pulmonary edema demonstrated by a normal capillary wedge pressure and production of protein-rich edema fluid. To investigate the effect of CO on alveolar-epithelial permeability, a radio-active labelled isotope, 51Cr-EDTA (MW 377), was instilled into the airways of rabbits. Subsequent egress of the marker from the ...
The onset and degree of injury occurring in animals that develop hyperoxic acute lung injury (HALI) is dependent on age at exposure, suggesting that developmentally regulated pathways/factors must underlie initiation of the epithelial injury and subsequent repair. Type II TGFβ receptor interacting protein-1 (TRIP-1) is a negative regulator of TGFβ signaling, which we have previously shown is a ...
KL-6 is a pulmonary epithelial mucin more prominently expressed on the surface membrane of alveolar type II cells when these cells are proliferating, stimulated, and/or injured. We hypothesized that high levels of KL-6 in epithelial lining fluid and plasma would reflect the severity of lung injury in patients with acute lung injury (ALI). Epithelial lining fluid was obtained at onset (day 0) an...
Nuclear erythroid-related factor 2 (Nrf2), a redox-sensitive transcription factor, is involved in transcriptional regulation of many antioxidant genes, including glutamate-cysteine ligase (GCL). Cigarette smoke (CS) is known to cause oxidative stress and deplete glutathione (GSH) levels in alveolar epithelial cells. We hypothesized that resveratrol, a polyphenolic phytoalexin, has antioxidant s...
1. In vitro models of welldifferentiated bronchial epithelial cells and alveolar type II and type I–like pneumocytes were set up. 2. The SARS-CoV could replicate in well-differentiated bronchial epithelial cells and alveolar type II pneumocytes only. 3. In well-differentiated bronchial epithelial cells, type I interferons (interferon-beta) and cytokine and chemokines (eg RANTES, IP-10, IL-6, IL...
BACKGROUND Preterm infants are highly susceptible to lung injury. While both chorioamnionitis and antenatal steroids induce lung maturation, chorioamnionitis is also associated with adverse lung development. We investigated the ability of bronchoalveolar lavage fluid (BALF) from ventilated preterm infants to restore alveolar epithelial integrity after injury in vitro, depending on whether or no...
Gap junction channels enable the direct flow of signaling molecules and metabolites between cells. Alveolar epithelial cells show great variability in the expression of gap junction proteins (connexins) as a function of cell phenotype and cell state. Differential connexin expression and control by alveolar epithelial cells have the potential to enable these cells to regulate the extent of inter...
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