The nucleophilic ring opening of epoxy fatty esters was carried out using the amino-1,2,4-triazole to yield substituted derivatives of β-amino alcohol. The synthesis of the substituted beta amino alcohols has been achieved by refluxing equimolar quantities of long chain epoxy esters (epoxy fatty esters) and 4-amino-1,2,4-triazole in dichloromethane to yield following compounds, methyl 10-(4'-am...

The title compounds 6aâj, 2-[(6-methyl-1,3-benzothiazol-2-yl)amino]-N-[2-(substituted phenyl/furan-2-yl)-4-oxo-1,3-thiazolidin-3-yl]nicotinamides, were prepared from 2-chloropyridine-3-carboxylic acid (1) and 2-amino-6-methyl-benzothiazole (2) by known methods. All the compounds have been established by IR, (1)H NMR, (13)C NMR and elemental analyses. The in vitro antimicrobial screening of the ...

Complexation of a series of related amino compounds by 18-crown-6 ether (18C6) is studied as a means of improving the resolution of mixtures by combinations of ion mobility spectrometry (IMS) and mass spectrometry (MS) techniques. Mixtures of the isomeric amines n-octylamine (NOA), dibutylamine (DBA), and diisopropylethylamine (DIPEA) were electrosprayed to produce gaseous [M + H](+) ions. Thes...

Abstract The aim of the present study is to explore new selective anti-inflammatory compounds with low cardiovascular risk. Twelve thiadiazole derivatives incorporating different amino acid moieties were newly synthesized ( 4 – 15 ) as potential agents risks through dual COX-2/MPO inhibition. Compounds initially screened for their effect by assay COX-2, most potent 6 , 8 further tested COX-1 in...

The tertiary phosphine oxides (TPO) comprise a large group of organophosphorus compounds to which a considerable attention in the literature is paid [1-5]. However, only few TPO ’s containing one or more primary amino groups in their mole­ cules are known. Studies on such compounds are limited [6-12]. Because of the high activity of amino groups these compounds can be used as phosphorylation ag...

Abstract Understanding N uptake by plants, the cycle, and their relationship to soil heterogeneity has generated a great deal of interest in distribution amino-N compounds soil. Visualization spatial can provide insights into role labile plant-microbial mechanisms acquisition plant uptake, but until now, it remained technically challenging. Here, we describe novel technique visualize at root-so...

Soluble epoxide hydrolase enzyme is a promising therapeutic target for hypertension, vascular inflammation, pain and some other risk factors of cardiovascular diseases. The most potent sEH inhibitors reported in the literature are urea-based ones which often have poor bioavailability. In this study, in a quest for finding potent inhibitors of soluble epoxide hydrolase, some 4,6-disubstituted py...

objective(s): nowadays, cancer is an important public health problem in all countries. limitations of current chemotherapy for neoplastic diseases such as severe adverse reactions and tumor resistance to the chemotherapeutic drugs have been led to a temptation for focusing on the discovery and development of new compounds with potential anticancer activity.   materials and methods: a new series...

Substituted para-benzoquinones and hydroquinones are ubiquitous transformation products that arise during oxidative water treatment of phenolic precursors, for example through ozonation or chlorination. The benzoquinone structural motive is associated with mutagenicity carcinogenicity, also induction the stress response Nrf2 pathway. For either endpoint, toxicological data differently substitut...