نتایج جستجو برای: aminoglycosides
تعداد نتایج: 4301 فیلتر نتایج به سال:
KEYWORDS: aminoglycosides ¥ antibiotics ¥ drug design ¥ medicinal chemistry ¥ RNA recognition Natural aminoglycoside antibiotics such as paromomycin and neomycin B [1] disrupt functional protein synthesis in bacteria by specifically binding to the decoding-site RNA in the 30S ribosomal subunit (Figure 1), [2] thereby interfering with mRNA decoding fidelity and ultimately leading to bacterial ce...
Aminoglycosides are mostly used as veterinary antibiotics. In France, their consumption accounts for about 10% of all prescribed animal medicine. Due to high polarity nature (log Kow < -3), they require chromatographic separation by hydrophilic interaction liquid chromatography or ion-pairing chromatography. This study presents the development an ion pairing with alkanesulfonates coupled tandem...
In a recent report published in this journal, Y. Qian and M.-X. Guan reported on their studies on interaction of aminoglycosides with human mitochondrial 12S rRNA carrying the A1555G deafness-associated mutation (15). Using RNA oligonucleotides representing the small subunit’s rRNA decoding A site (i.e., the drug binding pocket) and carrying the A1555G mutation, the authors used chemical footpr...
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