Abstract. During the early part of last glacial termination (17.2–15 ka) and coincident with a ∼35 ppm rise in atmospheric CO2, sharp 0.3‰–0.4‰ decline δ13CO2 occurred, potentially constraining key processes that account for deglacial CO2 rise. A comparable δ13C has also been documented numerous marine proxy records from surface thermocline-dwelling planktic foraminifera. The recorded foraminif...

Introduction: Skin and soft tissue infections (SSTI’s) are commonly caused by both gram positive and gram negative bacteria. The aim of the study was to investigate the presence of methicillin resistant Staphylococcus aureus (MRSA), Extended Spectrum Beta Lactamase (ESBL), Amp C and Metallo β-lactamase producing gram negative bacilli from clinical isolates obtained from patients attending G.S M...

Uvaria tortilis is a lianescent annonaceous species endemic to the C&#244te d’Ivoire where it used treat amenorrhea and as uterotonic. Thus, MeOH crude extract of its stem barks was investigated in order determine chemical composition. A new C-benzyl hydroxlated, uvriatortilisin (1), together with six known compounds, dichamanetin (2), β-sitosterol (3), stigmasterol (4), chamanetin (5), uvareti...

BACKGROUND Effective innate responses against potential pathogens are essential in the living world and possibly contributed to the evolutionary success of invertebrates. Taken together, antimicrobial peptide (AMP) precursors of defensin, mytilin, myticin and mytimycin can represent about 40% of the hemocyte transcriptome in mussels injected with viral-like and bacterial preparations, and uniqu...

Bacteria have evolved complex regulatory controls in response to various environmental stresses. Protein toxins of the ζ superfamily, found in prominent human pathogens, are broadly distributed in nature. We show that ζ is a uridine diphosphate-N-acetylglucosamine (UNAG)-dependent ATPase whose activity is inhibited in vitro by stoichiometric concentrations of ε2 antitoxin. In vivo, transient ζ ...

Parathyroid hormone (PTH) has been implicated in hypertension, but PTH infusion results in vasodilation. PTH activates adenylate cyclase in vascular smooth muscle, but little is known about the factors that regulate PTH receptor/adenylate cyclase coupling in vascular cells. To characterize hormone-receptor signaling, we measured cyclic AMP levels in rat arterial smooth muscle cells in culture e...

About the Journal, Author Information Pack & Table of Contents

1. Methylxanthines (IBMX, caffeine, theophylline), which are known inhibitors of c-AMP phosphodiesterase inhibited reversibly progesterone-induced maturation of Xenopus oocyte. 2. The time course of protein phosphorylation during maturation stimulated by progesterone was analysed in Xenopus oocyte : protein phosphorylation increased around germinal vesicle breakdown (GVBD). No quantitative chan...

Forskolin, a naturally occurring activator of adenylate cyclase, inhibits total and high-affinity cyclic AMP phosphodiesterase activity in soluble and particulate fractions of cultured LLC-PK1 renal epithelial cells. The naturally occurring forskolin analogue 1,9-dideoxyforskolin, which does not stimulate adenylate cyclase activity, is a more potent inhibitor of cyclic AMP phosphodiesterase act...