In a previous report from this hospital (Morson and Lockhart-Mummery, 1959) the clinical features and pathology of the anal lesions of Crohn's disease were described. In that paper reference was made to several patients with anal fissures or fistulae, biopsy of which showed a sarcoid reaction, but in whom there was no clinical or radiological evidence of intra-abdominal Crohn's disease. The opi...