In a preliminary dose-finding study in patients following abdominal hysterectomy, antrafenine was found to be an effective analgesic in single oral doses of 300-600 mg. A double-blind controlled between-patient study was carried out to compare antrafenine (up to 1200 mg daily), paracetamol (up to 4 g daily) and placebo as analgesic in the control of pain produced by ligamentous knee or ankle in...

Chantaleela recipe is indicated for relieving fever in Thai traditional folk medicine. In the present study, Chantaleela recipe was investigated for anti-inflammatory, analgesic, antipyretic and anti-ulcerogenic activities. In preliminary investigation Chantaleela recipe was found to exert an inhibitory activity on the acute phase of inflammation as seen in ethyl phenylpropiolate-induced ear ed...

Background: Synedrella nodiflora (L) Gaertn. belonging to the family Asteraceae contains steroids, reducing sugars, phenolic, flavonoids, saponins, tannins and triterpenoids. Therefore, this study is designed to investigate its antioxidant, analgesic and CNS depressant effects. Materials and Methods: The antioxidant activity of methanolic extract of S. nodiflora (SN) was determined using Folin ...

BACKGROUND Tissue damage is associated with pain, which is an alarming sign. Aspirin and morphine have been widely used in recent decades for management of pain. Medicinal herbs have been in use for treatment of different diseases for centuries. Many of these herbs possess analgesic activity with relatively less incidences of adverse effects. The strong positive correlation of alkaloids in medi...

Trillium govanianum rhizome is used as an analgesic and anti-inflammatory remedy in traditional medicine in northern Pakistan. In an attempt to establish its medicinal value, the present research evaluated the analgesic and anti-inflammatory potential of T. govanianum. The in vivo anti-inflammatory activity of extract and fractions was investigated in the carrageenan induced paw edema assay. Th...

Rhodiola rosea L. (Crassulaceae) have been used as traditional medicines that can increase someone’s physical strength, work productivity, longevity and resistance to high altitude sickness, fatigue, depression, anaemia, gastrointestinal ailments, infections, and nervous system disorders. The objective of this study was to evaluate the anti-inflammatory and analgesic activities from the methano...

Nitrogen heterocyclic compounds such as pyrazolines have been found to possess a broad spectrum of biological activities such as anticancer, antitubercular, anti-inflammatory, analgesic, and antidepressant activities. Pyrazoline derivatives IV, V (a-e) have been synthesized from the intermediate chalcones III (a-h) by cyclizing with phenyl hydrazine and hydrazine hydrate. The structures of thes...

This study was carried out to investigate the phytochemical constituents, analgesic and anti-inflammatory activity of methanol stem extract Globimetula braunii. Preliminary screening done using standard protocols, median lethal dose (LD50) determined by Lorke’s method. Analgesic activities were acetic acid induced writhing hot-plate model carrageenan-induced rat's paw edema respectively at grad...

Secondary metabolites from plants are a good source for the NSAID drug development. We studied the analgesic activity of ethanolic extract of Erythrina variegata L. (Fabaceae) followed by molecular docking analysis. The analgesic activity of Erythrina variegata L. is evaluated by various methods viz., acetic acid-induced writhing test, hot plate and tail immersion test. Subsequently, molecular ...

New mixed ligand complexes of Zn(II) with 1,10Phenanthroline and some amino acids were prepared in the solid form and characterized by elemental analysis, conductivity, magnetic moment measurement, FT-IR, 1 H-NMR, 13 C-NMR and FAB+ mass studies. To examine anti-inflammatory and analgesic activities of its complexes, some Swiss albino mice of 05-07 weeks old were taken. One dose of the test comp...