I N EARLIER communications we have described a thromhohemorrhagic phenomenon (THP) which can readily be elicited in rats by the intravenous injection of various metal combinations, reticuloendothelial blocking agents and certain agar preparations, especially if these are given in conjunction with catecholamines (epinephrine, norepinephrine) or severe systemic stressors. This syndrome is charact...

I N EARLIER communications we have described a thromhohemorrhagic phenomenon (THP) which can readily be elicited in rats by the intravenous injection of various metal combinations, reticuloendothelial blocking agents and certain agar preparations, especially if these are given in conjunction with catecholamines (epinephrine, norepinephrine) or severe systemic stressors. This syndrome is charact...

In comparison with the many millions of injections of penicillin given annually all over the world, the incidence of reported reactions to the drug is small. Untoward effects vary from simple discomfort at the site of injection to sudden death (Kern and Wimberley, 1953; Welch, Lewis, Kerlan, and Putnam, 1953). The amount and duration of pain at the injection site may vary with the technical ski...