Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma (NHL), and it accounts for approximately 25% of NHL cases.1 The incidence of DLBCL in the United States is approximately 7 cases per 100,000 person-years, with a male predominance.2 Caucasian Americans have higher rates than African Americans, Asians, and American Indians, in order of decreasing incidence. ...

Proteasome inhibition has emerged as an important therapeutic strategy in multiple myeloma (MM). Since the publication of the first phase 1 trials of bortezomib 10 years ago, this first-in-class proteasome inhibitor (PI) has contributed substantially to the observed improvement in survival in MM patients over the past decade. Although first approved as a single agent in the relapsed setting, bo...

Several decades of research have demonstrated that marital relationships have a powerful influence on physical health. However, surprisingly little is known about how marriage affects health--both in terms of psychological processes and biological ones. Over a 10-year period, we investigated the associations between perceived partner responsiveness--the extent to which people feel understood, c...

Thalidomide, bortezomib, and lenalidomide have recently changed the treatment paradigm of myeloma. In young, newly diagnosed patients, the combination of thalidomide and dexamethasone has been widely used as induction treatment before autologous stem cell transplantation (ASCT). In 2 randomized studies, consolidation or maintenance with low-dose thalidomide has extended both progression-free an...

Genetic Paternity and Mating Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 296 General Background . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 296 Synopsis of Pre-1996 Genetic Findings . . . . . . . . . . ....

background: caprine besnoitiosis is an economically important disease of goats. neospora caninum, another coccidian parasite of worldwide distribution, infects several animal species and is a major cause of abortion in cattle . combined infections of n. caninum and besnoitia caprae can occur in geo-graphical areas endemic for both species of parasite in goats. this experiment was conducted to i...

background: the cholinergic system plays an important role in learning and memory. administration of extracts of curcuma longa or its constituent, curcumin, have some roles in cognitive function in animals. the aim of the present study was to investigate the effects of curcumin in preventing spatial performance impairment induced by scopolamine, a cholinergic receptor antagonist, in rats using ...

thinking (10) 9 10 10 Verbal fluency (animal) 7 13 13 results of the three assessments are summarized in Table 1. The first neuropsychological assessment revealed that the patient was disoriented as to month, date, and place and was severely impaired in recent memory and verbal fluency. Her remote memory and immediate recall were normal, and her neurological examination was otherwise normal. 99...

The enzyme cyclooxygenase (COX) catalyzes the first step of the synthesis of prostanoids. In the early 1990s, COX was demonstrated to exist as two distinct isoforms. COX-1 is constitutively expressed as a “housekeeping” enzyme in most tissues. By contrast, COX-2 can be up-regulated by various proinflammatory agents, including lipopolysaccharide, cytokines, and growth factors. Whereas many of th...

Ovarian stimulation to achieve multiple follicle development has been an integral part of IVF treatment. In the context of improved laboratory performance, the need for a large number of oocytes as an integral part of a successful IVF programme may be questioned. The aim of the current debate is to summarize the studies performed during the last decade to develop the concept of mild stimulation...