BACKGROUND Protein kinase D (PKD) enzymes regulate cofilin-driven actin reorganization and directed cell migration through both p21-activated kinase 4 (PAK4) and the phosphatase slingshot 1L (SSH1L). The relative contributions of different endogenous PKD isoforms to both signaling pathways have not been elucidated, sufficiently. METHODOLOGY/PRINCIPAL FINDINGS We here analyzed two cell lines (...

Breast cancer is the most frequent malignancy in women. Several reports demonstrated that adrenergic receptors (ARs) are involved in breast cancer. Here we observed that epinephrine (Epi), an endogenous AR agonist, caused opposite effects in non-tumorigenic (MCF-10A and HBL-100) and tumor cells (MCF-7 and MDA-MB-231). Thus, Epi, in non-tumor breast cells, as well as isoproterenol (β-agonist), i...

Objective(s): Silibinin, as an herbal compound, has anti-cancer activity. Because of low solubility of silibinin in water and body fluids, it was encapsulated in polymersome nanoparticles and its effects were evaluated on pancreatic cancer cells and cancer stem cells.Materials and Methods: MIA PaCa-2 pancreatic cancer cells were treated ...

Objective(s): Berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis are not well known. Cancer cells obtain the ability to change their chemokine system and convert into metastatic cells. In this study, we examine...

Introduction Neutrophils are the primary defense of the host against pathogens. They remain in resting state in the circulation of the healthy individuals. When encountering cytokine or chemokine signals caused by pathogen products, neutrophils are activated and mobilized to the infected sites. The life span of neutrophils which have an essential role in terms of pathogenesis of autoinflammator...

Ventriculoperitoneal (VP) shunt is one of the most common pediatric neurosurgical procedures. It has various complications that may have serious consequences such as shunt dysfunction, and unusual migration. Although, migration of shunt catheter to bladder, heart, umbilicus, rectum, pulmonary artery, and stomach has been reported, migration to vagina is a rare one.In this report we present a 16...

This study was conducted in Delta State Nigeria to establish a nexus between rural-urban migration and child labour. Random sampling was applied to select rural settlements and this study covers 450 sample farming households. The results show that rural-urban migration influence child labour (P

Migration as a human phenomenon has some consequences and repercussions. One of these effects is crime commitment and inducing disturbance in land and national security in immigrants' residence country, in other word, international migration, especially illegal migration, have different penal-security effects. Finding reason that the permeability of borders and increasing illegal traffic, drug ...

This paper aims to interpret the evolution of migration within and from Morocco over the twentieth century from a combination of theoretical perspectives defined as “transitional migration theory”. Colonization and incorporation of rural areas, along with a certain level of development, have spurred internal and international wage labor migration within and from Morocco to Europe. Migration see...