The marked sexual dimorphism that exists in human cardiovascular diseases has led to the dogmatic concept that testosterone (Tes) has deleterious effects and exacerbates the development of cardiovascular disease in males. While some animal studies suggest that Tes does exert deleterious effects by enhancing vascular tone through acute or chronic mechanisms, accumulating evidence suggests that T...

Little is known concerning the potential ecological effects of hormonally active substances associated with discharges from animal feeding operations. Trenbolone acetate is a synthetic anabolic steroid that is widely used in the United States to promote growth of beef cattle. Metabolites of trenbolone acetate include the stereoisomers 17alpha- and 17beta-trenbolone, both of which are stable in ...

Provoked vestibulodynia (PVD) is a chronic vulvar pain disorder characterized by hypersensitivity and severe with pressure localized to the vestibule. Knowledge regarding pathophysiological mechanisms contributing etiology production of symptoms in PVD remains incomplete but considered multifactorial. Using cross-sectional observational study design, data from untargeted metabolomic profiling v...

Trends in skin and hair treatments focus on natural products due to undesired effects of chemically synthetic ingredients. This study aims investigate the cosmeceutical Equisetum debile (horsetail) extracts relating anti-hyperpigmentation via tyrosinase, anti-wrinkle formation matrix metalloproteinases (MMPs), anti-androgenic alopecia 5α-reductase. Ethanolic were sequentially partitioned into s...

The aim of this experiment was to analyse the consequences of changing attitudes related to doping through thoughtful versus non-thoughtful processes. Participants were young soccer players. They received a persuasive message either against or in favour of the legalisation of several doping behaviours in soccer (e.g., the use of anabolic androgenic steroid - AAS), and participants' level of ela...

The normal equine breeding season begins in the spring and extends through mid-summer. It is characterized by marked increases in sperm output and seminal volume, as well as behavioural changes manifested in decreased reaction time and the number of mounts per ejaculation (Pickett & Voss, 1972). The production of androgenic steroids by the equine testis has been investigated both in vivo (Lindn...

introduction: photobiostimulation with low level laser (lll) has been used in medicine for a long time and its effects have been shown in many diseases. some studies have evaluated the effect of lll on androgenic alopecia. one of the most important limitations of the use of lll in the treatment of alopecia is the requirement for multiple sessions, which is hardly accepted by patients. this stud...