The fact that the growth of the chick's comb is accelerated by the administration of androgenic material has been demonstrated by Ruzicka,3 by Burrows, Byerly, and Evans,' and by Frank and Klempner.' Ruzicka painted the chick's comb with a 0.5 per cent solution of androsterone in oil each day for a period of several weeks and obtained large increases in comb area. He did not, however, study thi...

The prostate is not a gland exclusive to the male reproductive system since it is also found in females of several mammals, including humans and rodents. In males, prostatic morphogenesis is an event controlled by androgens, which act indirectly via paracrine factors secreted by the mesenchyme. In females, prostatic embryological development occurs in an environment without steroid hormones, bu...

Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and present some clinical differences compared to adolescent acne. Local glandular metabolism turns some weak hormonal precursors into more active substances that increase the production...

During in vitro embryo production, chromosome screening is essential to prevent pregnancy losses caused by embryonic chromosome aberrations. When the chromosome screening is completed before fertilization, gametes are effectively utilized as genetic resources. The aim of this study was to investigate whether chromosome screening of gametes accompanied by fertilization would be feasible using a ...

Levonorgestrel (LNg) is known for its marked progestational/contraceptive activity. As shown in animal experiments, however, high doses of LNg are required to elicit an androgenic response; in contrast, considerably lower doses of LNg are required for antiovulatory (contraceptive) action. Thus, a large dose separation exists between androgenic and contraceptive activity. When LNg is combined wi...

It is difficult to speak with scientific restraint of the contributions of Edgar Allen to mankind. It is perhaps enough to say that here in New Haven the important school of anatomists, which knew his influence, thrives with vigor, and that his work has profoundly influenced biology universally, as will be apparent later in this lecture. Sexual maturity, in addition to conferring certain biolog...

OBJECTIVES Testosterone (T), the primary androgenic hormone in males, is stimulated through pulsatile secretion of LH and regulated through negative feedback inhibition at the hypothalamus and pituitary. The hypothalamic-pituitary-gonadal (HPG) axis also controls sperm production through the secretion of follicle-stimulating hormone (FSH). Negative feedback in the HPG axis is achieved in part t...

The absence of estrogen, in males or after menopause in women, is independently associated with increased cardiovascular risk. A number of factors have been implicated as the underlying cause, including effects at the cell-organ level (eg, inflammatory activation, increased oxidative stress, and increased vasoconstriction), as well as changes in cardiovascular physiology (eg, sympathetic activa...