Although the effects of androgens on wound healing are poorly characterised, the androgen receptor is expressed by inflammatory cells, keratinocytes and fibroblasts during wound healing, suggesting that androgens may regulate inflammatory and/or repair processes. In fact, it appears that endogenous testosterone inhibits wound healing and promotes inflammation since castration of male mice or sy...

Abundant clinical evidence suggests that androgens normally inhibit mammary epithelial proliferation and breast growth. Clinical and nonhuman primate studies support the notion that androgens inhibit mammary proliferation and, thus, may protect from breast cancer. On the other hand, administration of conventional estrogen treatment suppresses endogenous androgens and may, thus, enhance estrogen...

It has been widely suggested that elevated androgen levels may be critically involved in the genesis of prostate cancer. Despite the dependency of the normal prostate and of most prostatic cancers upon androgens and the fact that tumors can be produced in some rodent models by androgen administration, I will argue that, contrary to prevalent opinion, declining rather than high levels of androge...

background: hypertensive patients are highly susceptible to oxidizability. although hypertension is common among iranians, few data are available about lipid oxidation status in the involved people. the aim of this study was to evaluate the relationship between serum lipids levels and susceptibility of lipids to oxidation in hypertensive patients. materials and method: fasting serum lipids and ...

Androgens are the male sex hormones responsible for development of the male reproductive system. Testosterone is the main androgen, however, other circulating androgens also exist; these are dehydroepiandrosterone, androstenedione and androstenediol. In some tissues, testosterone can be converted to dihydrotestosterone by action of 5┙-reductase. Testosterone is also found in females, but at muc...

It is widely recognized that vascular function is modulated by the endocrine system. So it is known that hormones as aldosterone, renin-angiotensin II system, thyroids hormones, oxitocine, ghrelin, vasopressine, etc exert action on the vascular tone (Axelband et al., 2011; Nguyen & Touyz, 2011; Szmydynger-Chodobska et al., 2011; Tesauro et al., 2010;). Regarding sex hormones, epidemiological st...

Globally, cardiovascular disease will continue causing most human deaths for the foreseeable future. The consistent gender gap in life span of approximately 5.6 yr in all advanced economies must derive from gender differences in age-specific cardiovascular death rates, which rise steeply in parallel for both genders but 5-10 yr earlier in men. The lack of inflection point at modal age of menopa...

lipid oxidation was studied in m. longissimusdorsiand m. semimembranosusin male lambs of northeastern bulgarian fine wool breed and cross of this breed with ile de france, reared indoors and on pasture. the oxidation of the lipids was determined by quantification of thiobarbituric acid reactive substances (tbars), formed during the storage of the muscles at 4 ˚с until 6th dayand -20 ˚с until 90...

It has been widely suggested that elevated androgen levels may be critically involved in the genesis of prostate cancer. Despite the dependency of the normal prostate and of most prostatic cancers upon androgens and the fact that tumors can be produced in some rodent models by androgen administration, I will argue that, contrary to prevalent opinion, declining rather than high levels of androge...