T he mesolimbic dopamine (DA) system is part of the brain’s reward circuitry (see the figure). It controls an individual’s responses to rewards such as food, social interactions, and money, and is therefore an important determinant of motivation. Midbrain DA neurons projecting to the striatum are causally involved in reward-like processes. Less clear is how another apparent target of midbrain D...

The deficits in feeding and drinking that result from 6-hydroxydopamine (6-OHDA) lesions of the mesostriatal dopamine system are often explained using either sensorimotor arousal or anhedonia hypotheses. Sensorimotor arousal hypotheses posit that dopamine systems facilitate the capacity of sensory stimuli to activate any motor output. The anhedonia hypothesis suggests that dopamine systems ampl...

BACKGROUND Anhedonia and amotivation are substantial predictors of poor functional outcomes in people with schizophrenia and often present a formidable barrier to returning to work or building relationships. The Temporal Experience of Pleasure Model proposes constructs which should be considered therapeutic targets for these symptoms in schizophrenia e.g. anticipatory pleasure, memory, executiv...

BACKGROUND Sadness and anhedonia (loss of interest in activities) are central symptoms of major depression. However, not all people with these symptoms meet diagnostic criteria for major depression. We aimed to assess the importance of suicidality in the outcomes for primary care patients who present with sadness and anhedonia. METHOD Cohort study of 2,599 unselected primary care attenders in...

• In Ibero-American, the anxiety and anhedonia are related to consumption of food. The is palatable foods during confinement. different type had a probability increasing serving size. An increase in average body weight was observed confinement for COVID-19.

Subjects identified by Perceptual Aberration-Magical Ideation (Per-Mag) scores (n=97), Social Anhedonia (SocAnh) scores (n=45), and Physical Anhedonia (PhysAnh) scores (n=31) as well as normal controls (n=94), underwent psychophysiological and clinical assessment. This is the first published investigation of pursuit system functioning in three groups of questionnaire-identified at-risk individu...

To investigate the reliability of the Wisconsin Schizotypy Scales, this study applied generalizability analysis with two college student samples who completed the scales at two time points. The results indicated that the Revised Social Anhedonia Scale had acceptable levels of score dependability, but that the score dependability for the other scales (the Physical Anhedonia Scale, the Perceptual...

One of the goals of all pharmacological interventions aimed to increase the survival rateof patients with alcohol-dependent oropharyngeal cancers is to decrease alcohol use. Oxytocinis an alternative therapy for craving and alcohol management. However, the effectiveness ofoxytocin on the severity of alcohol dependence has not been evaluated. In an ABAB...