Hundreds of thousands of animals are presented to US veterinarians annually for surgery or for evaluation of painful disease. This large population offers the opportunity for clinical research of both acute and chronic pain syndromes. Although there is growing interest by veterinary clinical specialists to explore the nature of animal pain and how best to treat it, this resource is relatively u...

In recent years more attention has been paid to the issue of pain in animals, particularly in association with increasing awareness of animal welfare. It is therefore necessary for veterinarians to be able recognise unambiguously whether an animal suffers from pain. Adult humans suffering from pain can more or less characterise their painful experiences, including the site and intensity of the ...

The post-transcriptional regulator molecules, microRNAs, have emerged as important biomarkers and modulators of numerous pathophysiological processes including oncogenesis and cardiovascular diseases. Recently, a significant number of dysregulations in microRNAs have been reported in patients suffering from painful disorders such as complex regional pain syndrome, cystitis-induced chronic pain ...

In this presentation it is not intended to discuss the philosphical aspects of the body-mind problem ; it will only be attempted to survey to what extent subcortical operations in man by means of guided electrodess may have helped us to ascertain which systems passing through or synapsing in subcortical areas take part in those neural mechanisms that are the prerequisite for some psychic proces...

The methodology for the scientific assessment of animal welfare has developed rapidly in recent years and has become a major scientific discipline. The concepts of welfare, need, stress, health, pain, emotion and feeling are now clarified. In teaching, legislation and practical work referring to animal welfare, a clear definition that can be related to other concepts is needed. The welfare of a...

Ethical and animal welfare concerns about the destruction of free-living wildlife for disease control and environmental reasons have historically received little attention from animal welfare scientists, legislators or the public. Nevertheless, all vertebrates can experience pain and distress, regardless of whether they are unwanted pests or not. A wide range of methods is used to kill or other...

It seems impossible for a human being not to have some point of view concerning nonhuman animal (hereafter animal) welfare. Many people make decisions about how humans are permitted to treat animals using speciesist criteria, basing their decisions on an individual's species membership rather than on that animal's individual characteristics. Although speciesism provides a convenient way for mak...

To be able to believe that a dog with a broken paw is not really in pain when it whimpers is a quite extraordinary achievement even for a philosopher. Yet according to the standard interpretation, this is just what Descartes did believe. He held, we are informed, the 'monstrous' thesis that 'animals are without feeling or awareness of any kind'.1 The standard view has been reiterated in a recen...

The principles of humane experimental technique, first described by Russell and Burch in 1959, focus on minimising suffering to animals used for scientific purposes. Internationally, as these principles became embedded in the various systems of oversight for the use of animals in science, attention focused on how to minimise pain, distress and lasting harm to animals while maximising the benefi...

Background: Estradiol and progesterone as well as hippocampal GABAA receptors are believed to play a role in the modulation of pain. The aim of present study was to investigate the effect of intrahippocampal injections of GABAA receptor agonist (muscimol) and GABAA receptor antagonist (picrotoxin) on pain sensitivity during estrous cycle. Methods: Pain sensitivity was evaluated in rats ...