Anti-epileptic medications encompass a wide range of drugs including anticonvulsants, benzodiazepines, enzyme inducers or inhibitors, with a variety effects, including induction of cytochrome P450 and other enzyme, which may lead to catabolism of vitamin D and hypocalcemia and other effects that may significantly effect the risk for low bone mass and fractures. With the current estimates of 50 ...

Abstract INTRODUCTION Majority of LGG patients experience seizures during their disease course, requiring anti-epileptic drugs (AEDs). Frequent negatively impact health-related quality life (HRQoL). AEDs, moreover, are hypothesized to have mood-modulating effects. As survival for has been improving, it is essential that the seizure burden and AEDs on mental health disorders (MHD) be considered....

PURPOSE The aim of this study was to compare the serum levels of one-carbon metabolism (OCM) nutrients (e.g., folate, homocysteine and vitamin B12) and peripheral blood DNA methylation in epileptic patients under treatment with antiepileptic drugs (AEDs) and in healthy controls. METHODS In this cross-sectional study, 60 patients with epilepsy who were receiving valproate (VPA) (n = 30) or lam...

OBJECTIVE To investigate the occurrence of adverse effects of antiepileptic drugs (AED) in chronic epileptic patients in mono or polytherapy. METHOD We evaluated consecutive patients that met the following inclusion criteria: age of 18 years or older, diagnosis of epilepsy for at least one year, stable dose of AED for at least three months. Patients were asked if they had any adverse event re...

575 IntroductIon Anti-epileptic medications can be divided into two major groups. The traditional antiepileptic drugs, which were released for use prior to 1978, are Phenobarbital, Phenytoin, Primidone, Clonazepam, Ethosuximide, Carbamazapine and Valproate. There was a 15-year period from 1978 to 1993, when no new antiseizure drug was approved for use. Since 1993, an additional eight new anti-e...

Knowing the prognosis of epilepsy will undoubtedly influence the treatment strategy. This study aimed to define the prospects of newly diagnosed childhood epilepsy, assess the dynamics of its course, identify relevant variables and develop models to assess the individual prognosis. Four hundred and fifty-three children with newly diagnosed epilepsy were followed for 5 years. Terminal remission ...

PURPOSE This study aimed to describe seizures and their therapy among Swedish adolescents, aged 13-22, with active but uncomplicated epilepsy. METHOD The adolescents answered questionnaires (158/193). Data were also obtained from medical records. RESULTS Epileptic seizure types could be specified in 92.1% of the cases. Predominant types were Primary Generalised Tonic-Clonic Seizures and Par...

anxiety and depression are very common in population and occur in a wide range of clinical states and is very common in epileptic patients. many recent epidemiological studies have found a high prevalence of depression and anxiety in epileptic patients. these studies found that epileptic patients suffered from depression and anxiety than those without epilepsy. the prevalence of depression or a...

background and objective: regarding the prevalence of epilepsy in human society and with respect to insufficiency of usual treatments, new strategies and methods for medical treatment of epileptic patients are necessary. as nmda receptor antagonists are the most prominent anti-epileptic drugs, in the present study, we synthesized and investigated anti-epileptic effect of a new piperidine deriva...