The side effects associated with the usage of synthetic antidiabetic drugs make it imperative to search for alternative drugs from medicinal plants. Therefore, this study was aimed at evaluating the α-amylase and α-glucosidase inhibitory potential of Calotropis procera leaf, as well as its possible mode of inhibiting these enzymes. Acetone, aqueous and ethanolic extracts of C. procera leaf was ...

Background: Diabetes mellitus is a chronic disease. Decreasing postprandial hyperglycemia by retarding glucose absorption through inhibiting carbohydrates digesting enzymes (α-amylase and α-glucosidase) is one of many approaches used for the management of this disease. This study was aimed at evaluating the normoglycaemic potential of Helianthus annuus leaf. Methods: The effect o...

BACKGROUND/OBJECTIVES In Asia, various medicinal plants have been used as the primary sources in the health care regimen for thousands of years. In recent decades, various studies have investigated the biological activity and potential medicinal value of the medicinal plants. In this study, 100 methanol extracts from 98 plant species were evaluated for their biological activities. MATERIALS/M...

The existence of a global gene regulatory system in the hyperthermophilic archaeon Sulfolobus solfataricus is described. The system is responsive to carbon source quality and acts at the level of transcription to coordinate synthesis of three physically unlinked glycosyl hydrolases implicated in carbohydrate utilization. The specific activities of three enzymes, an alpha-glucosidase (malA), a b...

Ursolic acid (UA) is a major pentacyclic triterpenoid in plants, vegetables and fruits, which has been reported to have a potential anti-diabetic activity. Despite various semi-synthetic ursolic acid derivatives already described, new derivatives still need to be designed and synthesized to further improve the anti-diabetic activity. In the present study, two series of novel UA derivatives, wer...

Investigation of phytochemicals, cyto-toxicity, inhibitory effect on nitric oxide (NO) production and α-glucosidase activity, DPPH scavenging activity leaf extract from Gymnema inodorum (Lour.) Decne (LEGI) revealed that GC-MS analysis demonstrated the presence 83 phytochemicals with 5 main compounds i.e. Phytol (18.14 %), n-Hexadecanoic acid (12.45 9,12-Octadecadienoic (Z,Z)-(3.92 9,12,15-Octa...

Background: Diabetes mellitus (DM) is a complex metabolic disorder which involves multiple pathology manifested with increased blood glucose, neural degeneration, chronic inflammation, organ dysfunction etc. Hyperactive enzymes like alpha amylase and glucosidase that are involved in digestion of starch sucrose further upswings the postprandial hyperglycaemia by rushing excess glucose moieties i...

Phenolic-rich extracts from four edible marine macroalgae commonly found in UK waters were tested for their potential biological effects towards cultured colon cancer cells and for their ability to inhibit digestive enzymes to achieve potential anti-diabetic effects. Extracts from Palmaria, Ascophyllum and Alaria, but not Ulva, gave reasonable recoveries of phenolics and inhibited the prolifera...

The identification and development of novel and more efficient anti-inflammatory drugs for management of Cystic Fibrosis (CF) airway disease remains a compelling need. Sphingolipids (SLs) play an important regulatory role in CF due to their function in pulmonary infections and inflammation. Given the emerging importance of SLs in much pathology, novel drugs are continuously developed to selecti...

osting by E C BY-NCAbstract Azadirachta indica is widely used in traditional medicine to treat diabetes and hypertension. In the present study A. indica-yogurt was prepared and refrigerated up to 28 days. pH of A. indica-yogurt was lower whereas total titratable acid (TTA) was higher than plain-yogurt during storage. The total phenolic content (TPC) and antioxidant capacity increased during sto...