5-phenyl-1,3,4-thiadiazol-2-amine (1), on reaction with substituted indolaldehyde in presence of glacial acetic acid give N-((2-substituted indol-3-yl)methylene)-5-phenyl-1,3,4-thiadiazol-2-amine (26). The compounds 2-6 when treated with acetyl chloride in presence of triethylamine undergo cycloaddition to produce 4-(2-substituted indol-3-yl)-1-(5-phenyl-1,3,4-thiadiazol-2-yl)azetidin-2-one (7-...

The authors examined the association between circulating 25-hydroxyvitamin D(3) (25(OH)D(3)), the best indicator of total vitamin D exposure, and incident, sporadic colorectal adenoma risk in a pooled analysis of primary data from 3 colonoscopy-based case-control studies conducted in Minnesota, North Carolina, and South Carolina between 1991 and 2002. The pooled study included 616 colorectal ad...

Based on the clinical picture and triggering drugs, allergic and pseudoallergic adverse reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) can be classified in four patterns : respiratory, cutaneous, mixed and systemic. This categorization is useful for the purpose of describing patient populations included in studies about NSAID adverse reactions as well as for the routine management o...

OBJECTIVE To investigate the role of initial nonsteroidal antiinflammatory drug (NSAID) choice in the prevention of NSAID gastropathy, based on relative clinical and economic effects. METHODS To mimic clinical practice, a symptom-driven decision analytic model was constructed to compare 2 treatment strategies for long-term users of NSAIDs over a 1-year period: Strategy 1-generic NSAID used in...

OBJECTIVE To study the efficacy and toxicity of methotrexate (MTX) for patients with ankylosing spondylitis (AS) in a 36 week, open, single observer study. METHODS Patients were selected for study if they had evidence of active disease and had failed to respond to treatment with nonsteroidal antiinflammatory drugs (NSAID) and sulfasalazine. Eleven patients entered the study, and 9 were evalua...

Topical photoallergic contact dermatitis (PACD) is investigated by photopatch testing, and a consensus European methodology exists, which advises the use of ultraviolet (UV)A as the irradiation source (1). However, for most agents, the action spectrum for PACD has not been defined. We sought to determine the action spectrum for topical photocontact allergy to the non-steroidal antiinflammatory ...

In Australia, physiotherapy is a primary contact profession when practiced in private ambulatory settings. Primary contact means that physiotherapists take responsibility for diagnosis, decisions on interventions, appropriate ongoing management, and costs related to benefits. For most physiotherapists, the most common clinical presentations relate to symptoms from musculoskeletal conditions. Th...

Results of 3 previous studies suggest that use of aspirin is related to a reduced risk of endometrial cancer, at least in obese women (body mass index, > or =30 kg/m(2)). Using data obtained in a population-based, case-control study in western Washington State, the authors examined this question. Between 2003 and 2005, 410 women diagnosed with invasive endometrial cancer and 356 controls were i...