OBJECTIVE The association of breast cancer and thyroid autoimmunity has been suggested by many studies in the literature, but the causality still needed to be proven. With this study we aimed to search the correlation between thyroid autoimmunity and breast cancer prognostic factors. MATERIALS AND METHODS To this prospective cohort study 200 consecutive breast cancer patients, who were operat...

BACKGROUND Patients with chronic autoimmune thyroiditis have impaired health-related quality of life. The thyroid gland has a high selenium concentration, and specific selenoprotein enzyme families are crucial to immune function, and catalyze thyroid hormone metabolism and redox processes in thyroid cells. Previous randomized controlled trials have found that selenium supplementation decreases ...

Introduction and Aim: Thyroid peroxidase (TPO) is a thyroid-specific antigen, the presence of TPO antibodies known to be associated with developing hypothyroidism. In this study we aimed investigate genotypes prevalent for SNP rs2071400 gene its association development autoimmune thyroid disease. Materials Methods: This involved 43 patients hypothyroidism 44 healthy controls. Genotyping (C/T) w...

INTRODUCTION Palmoplantar pustulosis (PPP) is a chronic pustular inflammatory skin disease; however, its pathogenesis is not well understood. Several factors, such as genetics, tobacco use and autoimmune issues, may contribute to this disease. AIM This research was conducted to investigate the relationships between insulin resistance, thyroid disease and PPP. MATERIAL AND METHODS Thirty-thr...

Background: Hypothyroidism was the diagnosed and treated as a result of health related quality life issues. The aim this study that to evaluate effect IL-36 γ, Tg-Ab TOP-Ab in Hashimoto’s Thyroiditis (HT). Study design: This cross sectional conducted at Rawal Institute sciences, Islamabad duration six month, from April 2022 September 2022. Methods: A total number patients n=150 which divided in...

Metformin has been found to reduce elevated gonadotropin levels. Hashimoto’s thyroiditis is the most common thyroid disorder in iodine-sufficient areas, and it often develops postmenopausal women. The aim of this study was investigate whether autoimmune determines impact metformin on gonadotrope secretory function. Two matched groups women were studied: 35 with euthyroid (group A) without disor...

Thyroid peroxidase (TPO) was purified from each thyroid of 10 patients (experiment 1) and 4 patients (experiment 2) with toxic diffuse goiter by a simplified method with monoclonal anti-TPO antibody-assisted immunoaffinity column chromatography. The final preparations were used to measure the heme concentration based on the cyanide difference spectrum, and to determine the Km and kcdt values fr...

about 25-50% of graves' disease (gd) patients develop thyroid eye diseases, which is associated with inflammatory process and abnormalities in the levels of several cytokines in orbital tissues in gd.  the aim of this study was to determine the th1 and th2 serum cytokines in patients with gd with or without ophthalmopathy. serum  levels of  cytokines  and  autoantibodies  including interferon-g...

Autoimmune disease and/or autoantibodies have been reported in mood disorder patients. We screened for autoantibodies to glutamic acid decarboxylase (GAD65), thyroid peroxidase (TPO), gastric H+/K+ ATPase (ATP4B), and Ro52 in a psychiatric patient cohort. A 24-year-old woman with major depressive disorder (MDD) with reduced psychomotor activity was identified with unusually high serum GAD65 and...