OBJECTIVES To determine the incidence of tuberculous lymphadenitis in enlarged neck nodes. MATERIALS AND METHODS Continuous prospective study is carried out in the department of otorhinolaryngology head & neck surgery, Kathmandu Medical College, Kathmandu, during two years, from January 2006 to January 2008. The study included a group of 155 patients with cervical lymphadenopathy. Each patien...

BACTEC 460 has now been phased out, so the search for an alternative is imperative. We have determined the activity of standard anti-tuberculosis drugs against intramacrophage Mycobacterium tuberculosis, in vitro, by using BACTEC 460 and MGIT 960 methods. The minimum inhibitory concentrations of isoniazid, rifampicin, ethambutol and streptomycin against intracellular M. tuberculosis H37Rv were ...

Metal-carboxylic ionophore complexes, where Metal = Ag, Tl, Li, Na, K, Rb, Mg, Mn, Cs, Sr, Ba, Cu and Ionophore = monensin (MON-H), have been synthesized. The molecular structures of three complexes have been solved by X-ray diffraction methods. The metal chelates were tested against human tuberculosis line for potential anti-tubercular activity against Mycobacterium tuberculosis H37Rv (MTB). T...

In the present research, we tend to ready a series of novel pyrimidine-linked isoxazole derivatives (11-20). The molecular structure and elemental composition these compounds were confirmed by spectroscopic studies analysis. MABA (Microplate alamar Blue Assay) assay was employed for assessing antitubercular activity against Mycobacterium tuberculosis H37Rv strain. Among ten synthesized compound...

Introduction: Isolated tubercular liver abscess without any other foci of infection is an extremely rare presentation of tuberculosis with a prevalence of only 0.34%. The diagnosis can be extremely challenging on account of the non specific presentation and is frequently confused with hepatoma, pyogenic liver abscess or amoebic liver abscess. Case Presentation: A 44 year old man presented with ...

Novel drug strategies are desperately needed to combat the global threat posed by multidrug-resistant strains of Mycobacterium tuberculosis (Mtb). The genome sequence of Mtb has revealed an unprecedented number of cytochrome P450 enzymes in a prokaryote, suggesting fundamental physiological roles for many of these enzymes. Several azole drugs (known inhibitors of cytochromes P450) have been sho...

Seaweeds have caused an emerging interest in the biomedical area, mainly due to their contents of bioactive substances which show great potential as anti-inflammatory, anti-microbial, anti-viral and anti-tumoral drugs. Despite the diversity in quality and quantity of the Mediterranean Tunisian coast flora, with its large contains of marine organisms and seaweeds, most of them have not yet been ...