Background: In spite of the great advances in vitrification, the mechanism of embryo damage which occure in some cases and varies from one case to another case is not exactly understood. Since Zona pellucida has an important role on early embryonic development, the aim of the present study is to investigate the effect of vitrification on integrity of zona pellucida and surveillance of blastocys...

background : type 1 diabetes mellitus (t1dm) is an autoimmune disease characterized by selective destruction of pancreatic beta cells.   methods: the study included 80 children, 20 of them have t1dm, 40 children were selected from first degree relatives to the same child and 20 healthy children serve as control. body mass index (bmi) was calculated, random blood glucose and glycosylated hemoglo...

background: patients with ulcerative colitis (uc) carry autoantibodies such as perinuclear antineutrophil cytoplasmic antibodies (p-anca). objective: the aim of the present study was to evaluate the target antigens for p-anca in iranian patients with uc. methods: p-anca target antigens including elastase, lactoferrin, cathepsin g, myeloproxidase, lysozyme, and bactericidal permeability increasi...

case presentation we herein describe a case of a 7 year-old child affected by an overlap syndrome between type 2 autoimmune hepatitis and small duct primary sclerosing cholangitis. although characterized by a severe onset, the disease showed a good response to treatment with prednisone and azathioprine. conclusions the association of type 2 autoimmune hepatitis and small duct primary cholangiti...

Antibody drug conjugates (ADCs) are a new class of drugs that combine chemosynthetic with antibody through linker. the targeting characteristics traditional cytotoxic small molecule drugs, while reducing side effects both making them kind “biological missile” and representing relatively evolving anti-cancer drugs. Antibody-coupled currently used in many solid tumors, this article reviews clinic...