PURPOSE To evaluate the antibacterial potential of pioglitazone, a member of the thiazolidinediones class of drugs, against Gram-positive (Streptococcus pneumoniae) and Gram-negative (Escherichia coli and Klebsiella pneumoniae) bacteria. METHODS Susceptibility testing was done using the antibiotic disk diffusion method and the minimal inhibitory concentration (MIC) of pioglitazone was measure...

Background and objective: Six families of thiazole, thiazolidine, imidazole, tetrahydropyrimidine, oxazolidine and thiazepine are new and important heterocyclic antibacterial compounds. Aim of this study is evalution the antibacterial effect of thirty new thiazole, thiazolidine, imidazole, tetrahydropyrimidine, oxazolidine and thiazepine derivatives against Bacillus subtilis and salmonella ente...

The genus Enterococcus is represented by some of the clinically important species and is well known for its antibiotic resistance, which participates in colonization and infection. Increasing resistance of enterococci has been evoked due to the excessive use of antibiotics not merely for therapeutic purposes or in indicated cases. One of the promising possibilities how to reduce the use of grea...

Type I IFNs were discovered as the primary antiviral cytokines and are now known to serve critical functions in host defense against bacterial pathogens. Accordingly, established mediators of IFN antiviral activity may mediate previously unrecognized antibacterial functions. RNase-L is the terminal component of an RNA decay pathway that is an important mediator of IFN-induced antiviral activity...

In the past decades, honey has been subjected to various laboratory and clinical investigations. The antimicrobial properties of honey have been attributed to both the hydrogen peroxide as well as non-peroxide components. In the present study, three honey samples were collected and four bacterial strains were isolated from ear discharge samples. For the isolation of bacterial strains, the sampl...

BACKGROUND Concerns have recently emerged about the efficacy and the quality of antibacterial generic products approved for use in humans. METHODS We searched Medline and Embase for original research articles on antibacterial generic products published in English or French before July 2013. RESULTS We selected 37 original research articles: 15 on β-lactams, 10 on glycopeptides, and 12 on ot...

background and objective: nowadays, incidence of antibiotic-resistance among pathogenic bacteria has increased due to indiscriminate use of antimicrobial drugs for treatment of diseases, especially urinary tract infections. medicinal plants are also of great importance as antibacterial agents. therefore, the aim of this study was to determine the antibacterial effect of ethanolic extract of net...

Azurocidin is an inactive serine protease homolog with primary sequence similarity to neutrophil elastase, cathepsin G, and proteinase 3. The aim of this study was to investigate possible consequences of differential glycosylation of azurocidin in regard to its secretion, protein stability as measured by susceptibility to proteolysis, and antibacterial activity. Site-directed mutagenesis was em...

The in vitro antibacterial activity of the antifungal compound fenticonazole was compared with those of clotrimazole, miconazole, tetracycline, and metronidazole against 177 strains of bacterial species associated with either bacterial vaginosis (BV) or skin infections by agar dilution MIC determinations. BV-associated Bacteroides isolates of the Bacteroides melaninogenicus-B. oralis group, Gar...

The antibiotic resistance patterns of aetiological agents responsible for vibriosis and pasteurellosis were studied to contribute to control the spread of these two bacterial diseases in Mediterranean fish farming. Strains of Photobacterium damsela ssp. piscicida, Vibrio fluvialis, Vibrio alginolyticus, Vibrio parahaemolyticus, Vibrio metschnikovii, isolated from Italian aquaculture (fish, shel...